US RE40,811 E1
	Peripheralization of hematopoietic stem cells
Thalia Papayannopoulou, Seattle, Wash. (US)
Assigned to Board of Regents of the University of Washington, Seattle, Wash. (US)
Appl. No. 11/635,821 PCT Filed Nov. 15, 1993, PCT No. PCT/US93/11060 § 371(c)(1), (2), (4) Date Jul. 13, 1995, PCT Pub. No. WO94/11027, PCT Pub. Date May 26, 1995.
Application 08/436339 is a continuation in part of application No. 07/977702, filed on Nov. 13, 1992, abandoned.
Application 11/635821 is a reissue of application No. 08/436339, filed on Jul. 13, 1995, now 5,843,438, filed on Dec. 01, 1998.
Int. Cl. A61K 39/395 (2006.01); A61K 38/19 (2006.01); A61K 38/21 (2006.01)

U.S. Cl. 424—130.1  [424/133.1; 424/135.1; 424/143.1; 424/144.1; 424/152.1; 424/153.1; 424/156.1; 424/85.1; 424/85.2]

14 Claims

1. A method of peripheralizing CD34+ cells in vivo comprising the step of administering an anti-VLA-4 antibody or an anti-VCAM-1 antibody which blocks the binding of VLA-4 antigen on the surface of the CD34+ cells to VCAM [ VCAM-1] or fibronectin [ , and thereby increasing the number of CD34+ cells in the peripheral blood] .