| US 7,553,942 B2 | ||
| Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled amides using metal amides and photo-induced free radical carbonylation | ||
| Oleksiy Itsenko, Uppsala (Sweden); Tor Kihlberg, Uppsala (Sweden); and Bengt Langstrom, Uppsala (Sweden) | ||
| Assigned to GE Healthcare Limited, Buckinghamshire (United Kingdom) | ||
| Filed on Nov. 07, 2005, as Appl. No. 11/268,107. | ||
| Claims priority of provisional application 60/625377, filed on Nov. 05, 2004. | ||
| Prior Publication US 2006/0133998 A1, Jun. 22, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. C07F 5/00 (2006.01); C07C 233/02 (2006.01); B01J 19/08 (2006.01) | ||
| U.S. Cl. 534—11 [204/89; 204/157; 422/159; 422/186; 564/123] | 11 Claims |
| 1. A method for labeling synthesis, comprising:
(a) providing a UV reactor assembly comprising a high pressure reaction chamber, a UV lamp and a concave mirror, wherein the
high pressure reaction chamber comprises a window facing the concave mirror, a liquid inlet and a gas inlet in a bottom surface
thereof,
(b) reacting a solution of weakly nucleophilic amine with a metal base to improve the reactivity of said weakly nucleophilic
amine,
(c) adding a solution of akyl iodides to the solution of step (b) to give a solution to be labeled,
(d) introducing a carbon-isotope monoxide enriched gas-mixture into the reaction chamber of the UV reactor assembly via the
gas inlet,
(e) introducing at high pressure said reagent into the reaction chamber via the liquid inlet,
(f) turning on the UV lamp and waiting for a predetermined time while the labeling synthesis occur, and
(g) collecting the labeled amide from the reaction chamber.
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