| US 7,553,867 B2 | ||
| Furan or thiophene derivative and medicinal use thereof | ||
| Kazumasa Hamamura, Osaka (Japan); Shigekazu Sasaki, Osaka (Japan); Yuichiro Amano, Osaka (Japan); Junichi Sakamoto, Osaka (Japan); and Kohji Fukatsu, Osaka (Japan) | ||
| Assigned to Takeda Pharmaceutical Company Limited, Osaka (Japan) | ||
| Appl. No. 10/526,507 PCT Filed Sep. 04, 2003, PCT No. PCT/JP03/11308 § 371(c)(1), (2), (4) Date Sep. 29, 2005, PCT Pub. No. WO2004/022551, PCT Pub. Date Mar. 18, 2004. |
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| Claims priority of application No. 2002-261873 (JP), filed on Sep. 06, 2002; and application No. 2003-185241 (JP), filed on Jun. 27, 2003. | ||
| Prior Publication US 2006/0100261 A1, May 11, 2006 | ||
| Int. Cl. A61K 31/341 (2006.01); A61K 31/381 (2006.01); C07D 307/40 (2006.01); C07D 333/14 (2006.01); C07D 333/18 (2006.01) | ||
| U.S. Cl. 514—438 [514/461; 549/78; 549/484; 549/497; 549/505] | 27 Claims |
1. A compound represented by the formula (I):
 R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group,
p is 0, 1 or 2, and when p is 2, each R may be the same or different,
R1 is a hydrogen atom or an optionally substituted hydrocarbon group,
R2 is an optionally substituted aromatic group,
Ring A is an optionally substituted benzene,
X1 is an oxygen atom or a sulfur atom,
X2 is an oxygen atom or —S(O)n—, wherein n is 0, 1 or 2,
Y is a bond, an oxygen atom, —S(O)m—, —C(═O)—N(R3)— or —N(R3)—C(═O)— and R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is
0, 1 or 2,
M1 and M2 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon
group, M3 is an optionally substituted divalent aliphatic hydrocarbon group and M4 is an optionally substituted divalent aliphatic hydrocarbon group,
or a pharmacologically acceptable salt thereof, or a prodrug thereof,
provided that (1) when Y is an oxygen atom or —S(O)m—, M1 is not a bond, and (2) when Y is a bond and one of M1 and M2 is a bond, the other of M1 and M2 is neither a bond nor methylene.
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