| US 7,553,849 B2 | ||
| Compounds | ||
| Anders Björk, Bjärred (Sweden); and Karl Jansson, Dalby (Sweden) | ||
| Assigned to Active Biotech AB, Lund (Sweden) | ||
| Filed on Jun. 15, 2005, as Appl. No. 11/152,777. | ||
| Claims priority of application No. 0401578 (SE), filed on Jun. 18, 2004. | ||
| Prior Publication US 2006/0004038 A1, Jan. 05, 2006 | ||
| Int. Cl. A61K 31/4365 (2006.01); C07D 495/06 (2006.01) | ||
| U.S. Cl. 514—301 [546/114] | 21 Claims |
1. A compound of formula (I)
 R is selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl and allyl;
R′ is selected from hydrogen, straight, branched or cyclic C1-C4 alkyl; straight, branched or cyclic C1-C3 alkoxy; fluoro, chloro, bromo, trifluoromethyl and OCHxFy,
wherein x=0, 1, 2,
y=1, 2, 3 with the proviso that
x+y=3;
R″ is selected from hydrogen, fluoro and chloro, with the proviso that R″ is selected from fluoro and chloro only when R′
is selected from floro and chloro;
R3 is selected from hydrogen and straight, branched or cyclic C1-C5 alkyl;
R4 is hydrogen, CH2OCOC(CH3)3, or COR4′ wherein R4′ is straight or branched C1-C5 alkyl, phenyl, benyl or phenethyl;
R7 is methyl or ethyl;
B is C—R2;
A is S, R2 is hydrogen or methyl, with the proviso that R2 is methyl only
when R3 is not hydrogen;
and any tautomer thereof.
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