US 7,553,547 B2
	Backfilled, self-assembled monolayers and methods of making same
Glen E. Fryxell, Kennewick, Wash. (US); Thomas S. Zemanian, Richland, Wash. (US); R. Shane Addleman, Benton City, Wash. (US); Christopher L. Aardahl, Sequim, Wash. (US); Feng Zheng, Richland, Wash. (US); Brad Busche, Raleigh, N.C. (US); and Oleg B. Egorov, West Richland, Wash. (US)
Assigned to Battelle Memorial Institute, Richland, Wash. (US)
Filed on Dec. 21, 2005, as Appl. No. 11/315,646.
Prior Publication US 2007/0141364 A1, Jun. 21, 2007
Int. Cl. B32B 25/20 (2006.01)

U.S. Cl. 428—447  [528/38; 427/397.7]

32 Claims

1. An engineered, self-assembled monolayer comprising at least one functional organosilane species, molecules of the functional organosilane species comprise an anchor, a tether, and a ligand having at least one analyte binding site, the monolayer characterized by a substantially random dispersion of molecules of at least one backfilling organosilane species among molecules of the functional organosilane species, wherein the functional organosilane species and the backfilling organosilane species have been sequentially deposited on a substrate.