| US 7,553,403 B2 | ||
| Reversible electrochemical sensors for polyions | ||
| Eric Bakker, Auburn, Ala. (US); and Alexey Shvarev, Auburn, Ala. (US) | ||
| Assigned to Auburn University, Auburn, Ala. (US) | ||
| Filed on Jul. 08, 2004, as Appl. No. 10/887,251. | ||
| Claims priority of provisional application 60/485856, filed on Jul. 09, 2003. | ||
| Prior Publication US 2005/0023153 A1, Feb. 03, 2005 | ||
| Int. Cl. G01N 27/327 (2006.01); G01N 27/333 (2006.01) | ||
| U.S. Cl. 205—789.5 [205/789; 205/792; 204/296; 204/418] | 20 Claims |
| 3. A method of measuring the concentration of a polyion species in a sample solution, comprising:
providing a sample solution comprising a polyion species and a background electrolyte;
contacting said sample solution with a polyion-selective membrane electrode having a membrane comprising a lipophilic electrolyte
having a lipophilic cation component and a lipophilic anion component, wherein at least one of the lipophilic anion and a
lipophilic cation components is selective for the polyion species;
contacting the sample with a reference electrode, wherein the membrane electrode and the reference electrode are electrically
connected;
applying an external current pulse of fixed duration to a circuit comprising the membrane electrode and the sample solution,
thereby driving transport of the polyion species from the sample solution into the membrane;
measuring the potentiometric response during the current pulse between the membrane electrode and the reference electrode;
and calculating the concentration of the polyion species as a function of the potentiometric response.
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