| CPC C12Q 1/6886 (2013.01) [A61K 31/519 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/156 (2013.01)] | 11 Claims |
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1. A method of treating breast cancer in a subject, the method comprising:
determining that a copy number amplification of a region specific to human chromosome 1q21.3 is present in a tumour tissue and/or blood sample from the subject,
wherein determining that a copy number amplification of a region specific to human chromosome 1q21.3 is present in a tumour tissue and/or blood sample from the subject comprises evaluating a copy number ratio of at least one continuous genomic region located on human chromosome 1q21.3 in the subject to a reference continuous genomic region in the subject, wherein if the copy number ratio exceeds a threshold value it is indicative of copy number amplification, and
wherein the at least one continuous genomic region selected from the group consisting of: a human TUFT1 gene, a gene from the human S100 family, and combinations thereof,
administering to the subject pacritinib or therapeutically effective analogs thereof,
wherein the pacritinib or therapeutically effective analogs thereof leads to a reduction in the expression of a human S100 family gene driving breast cancer progression in the subject,
wherein the human S100 family gene is selected from S100A7, S100A8, S100A9 and combinations thereof.
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