CPC C07K 16/2827 (2013.01) [G01N 33/577 (2013.01); C07K 2317/21 (2013.01); C07K 2317/92 (2013.01); G01N 2333/70532 (2013.01)] | 17 Claims |
1. A method for treating a cancer related to a B7-H3 positive cancer cell, wherein the method comprises administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of a monoclonal anti-B7-H3 antibody or antigen-binding fragment thereof comprising:
(i) an antibody heavy chain variable region comprising HCDR1, HCDR2, and HCDR3 having the amino acid sequences of SEQ ID NOs: 10, 11 and 12, respectively; and an antibody light chain variable region comprising LCDR1, LCDR2, and LCDR3 having the amino acid sequences of SEQ ID NOs: 13, 14 and 15, respectively; or
(ii) an antibody heavy chain variable region comprising HCDR1, HCDR2, and HCDR3 having the amino acid sequences of SEQ ID NOs: 16, 17 and 18, respectively; and an antibody light chain variable region comprising LCDR1, LCDR2, and LCDR3 having the amino acid sequences of SEQ ID NOs: 19, 20 and 21, respectively.
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