US 11,679,120 B2
Circular RNA compositions and methods
Allen T. Horhota, Cambridge, MA (US); Brian Goodman, Cambridge, MA (US); Robert Alexander Wesselhoeft, Cambridge, MA (US); and Junghoon Yang, Cambridge, MA (US)
Assigned to Orna Therapeutics, Inc., Cambridge, MA (US)
Filed by Orna Therapeutics, Inc., Cambridge, MA (US)
Filed on Mar. 15, 2021, as Appl. No. 17/202,223.
Application 17/202,223 is a continuation of application No. PCT/US2020/063494, filed on Dec. 4, 2020.
Claims priority of provisional application 63/087,582, filed on Oct. 5, 2020.
Claims priority of provisional application 63/022,248, filed on May 8, 2020.
Claims priority of provisional application 62/972,194, filed on Feb. 10, 2020.
Claims priority of provisional application 62/943,779, filed on Dec. 4, 2019.
Claims priority of provisional application 62/943,797, filed on Dec. 4, 2019.
Prior Publication US 2022/0323480 A1, Oct. 13, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/7105 (2006.01); A61K 47/22 (2006.01)
CPC A61K 31/7105 (2013.01) [A61K 47/22 (2013.01)] 19 Claims
 
1. A pharmaceutical composition comprising:
a. a RNA polynucleotide, and
b. an in vivo transfer vehicle comprising an ionizable lipid selected from the group consisting of:

OG Complex Work Unit Chemistry