| US 7,550,970 B2 | ||
| Multidimensional NMR spectroscopy of a hyperpolarized sample | ||
| Rolf Servin, Malmo (Sweden); Jan Henrik Ardenkjaer-Larsen, Malmo (Sweden); Haukur Johannesson, Malmo (Sweden); Maurice Goldman, Villebon sur Yvette (France); and Jan Wolber, Amersham (United Kingdom) | ||
| Assigned to GE Healthcare AS, Oslo (Norway) | ||
| Appl. No. 10/553,381 PCT Filed Apr. 13, 2004, PCT No. PCT/EP2004/003864 § 371(c)(1), (2), (4) Date Jul. 19, 2007, PCT Pub. No. WO2004/090563, PCT Pub. Date Oct. 21, 2004. |
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| Claims priority of application No. 0308586.7 (GB), filed on Apr. 14, 2003. | ||
| Prior Publication US 2008/0061781 A1, Mar. 13, 2008 | ||
| Int. Cl. G01V 3/00 (2006.01) | ||
| U.S. Cl. 324—307 [324/309] | 6 Claims |
| 1. A method of performing two-dimensional Nuclear Magnetic Resonance (NMR) spectroscopy on a hyperpolarized sample, which
method comprises the steps of:
hyperpolarizing a sample which comprises a first nuclear species (I) and a second nuclear species (S), with the Hamiltonian
H=HS+HIS+HI using DNP, wherein the NMR active nuclei receive hyperpolarization and transformation of the sample to a liquid state;
performing two-dimensional NMR spectroscopy on the sample and thereby producing at least two NMR spectra with the use of a
sequence of rf-pulses, wherein the sequence of rf-pulses comprises at least two rf-pulses on the same nuclei, and wherein
the pulse sequence is adapted for a hyperpolarized sample in such a way that it uses a single scan, an efficient trajectory
in a tS-tIS plane and produces a square array of observed points in a square portion of a two time space;
analyzing the at least two NMR spectra in order to obtain a characterization of the sample.
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