	US 7,550,603 B2
	1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors
Gui-Dong Zhu, Gurnee, Ill. (US); Jianchun Gong, Deerfield, Ill. (US); Virajkumar B. Gandhi, Park City, Ill. (US); Thomas D. Penning, Elmhurst, Ill. (US); and Vincent L. Giranda, Gurnee, Ill. (US)
Assigned to Abbott Laboratories Inc., Abbott Park, Ill. (US)
Filed on Apr. 11, 2006, as Appl. No. 11/401,638.
Claims priority of provisional application 60/670204, filed on Apr. 11, 2005.
Prior Publication US 2006/0229289 A1, Oct. 12, 2006
Int. Cl. A61K 31/4184 (2006.01); C07D 403/04 (2006.01)

U.S. Cl. 548—304.7 [548/306.1]

17 Claims

1. A compound of Formula (I)

or a therapeutically acceptable salt thereof, wherein

R₁, R₂, and R₃are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkynyl, cyano, haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, nitro, NR_AR_B, and (NR_AR_B)carbonyl;

A is a nonaromatic 4, 5, 6, 7, or 8-membered ring that contains 1 or 2 nitrogen atoms and, optionally, one sulfur or oxygen atom, wherein the nonaromatic ring is optionally substituted with 1, 2, or 3 substituents selected from the group consisting of alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cyano, haloalkoxy, haloalkyl, halogen, heterocycle, heterocyclealkyl, heteroaryl, heteroarylalkyl, hydroxy, hydroxyalkyl, nitro, NR_CR_D, (NR_CR_D)alkyl, (NR_CR_D)carbonyl, (NR_CR_D)carbonylalkyl, (NR_CR_D)sulfonyl, and oxo; and

R_A, R_B, R_C, and R_Dare independently selected from the group consisting of hydrogen, alkyl, and alkycarbonyl.