US 7,550,512 B2
Medical polymers and uses thereof
Toshinori Sato, Yokohama-shi (Japan); Yoshiyuki Koyama, Tokyo (Japan); and Tetsuji Yamaoka, Ibaraki-shi (Japan)
Assigned to Keio University, Tokyo (Japan); and NOF Corporation, Tokyo (Japan)
Filed on Jun. 03, 2004, as Appl. No. 10/859,598.
Application 10/859598 is a continuation in part of application No. 10/469136, abandoned, previously published as PCT/JP02/12420, filed on Nov. 28, 2002.
Claims priority of application No. 2001-362482 (JP), filed on Nov. 28, 2001; and application No. 2002-343256 (JP), filed on Nov. 27, 2002.
Prior Publication US 2005/0036973 A1, Feb. 17, 2005
Int. Cl. A61K 47/34 (2006.01); A61K 47/30 (2006.01); C08G 65/329 (2006.01)
U.S. Cl. 514—772.7  [424/70.13; 525/326.1] 3 Claims
OG exemplary drawing
 
1. A copolymer, or a salt thereof, with a molecular weight of 1,000-200,000 comprising structural units represented by the following formulas (I), (II), and (III):

OG Complex Work Unit Drawing
where R1 in formula (I) is a group represented by the following formula (C) or (D), and R2 in formula (II) is a group represented by the following formula (B), (D) or (E):
*—(CH2)n—S—(CH2)p—(CO)t—NH—Xu—  (B)
where X is hydrocarbon group, n is an integer from 2 to 8; p is an integer from 1 to 8; t is an integer 0 or 1; u is an integer 0 or 1; and * may be positioned on the ethylene oxide side or on the opposite side
*—(CH2)m—S—(CH2)p—  (C)
where m is an integer from 2 to 8; p is an integer from 1 to 8; and * may be positioned on the ethylene oxide side or on the opposite side

OG Complex Work Unit Drawing
where m is an integer from 2 to 8; r is an integer from 0 to 7; s is an integer from 0 to 7; t is an integer from 0 to 4; RS an amino group, carboxyl group or sugar residue; and * may be positioned on the ethylene oxide side or on the opposite side

OG Complex Work Unit Drawing
where m is an integer from 2 to 8; r is an integer from 0 to 7; s is an integer from 0 to 7; and * may be positioned on the ethylene oxide side or on the opposite side;
R3 in general formula (II) is a sugar residue; and the respective mole percents of units (I), (II) and (III) are (I)=1-98, (II)=1-98 and (III)=1-98.