A—E—NR¹—G  (I)

or stereoisomers or pharmaceutically acceptable salts thereof, wherein:

A is

E is selected from —(CR⁷R⁸)—(CR⁹R¹⁰)_v—(CR¹¹R¹²),

ring D is selected from a C_3-6 carbocyclic residue and a 5 or 6 membered heterocycle;

G is selected from —C(O)R³, —C(O)NR²R³, —C(O)OR³, —SO₂NR²R³, —SO₂R³, —C(═S)NR²R³, C(═NR^1a)NR²R³, C(═CHCN)NR²R³, C(═CHNO₂)NR²R³, C(═C(CN)₂)NR²R³,

W, at each occurrence, is independently selected from C or N, provided at least two of W are C;

X¹ and X² are independently selected from C and N;

Z¹ is selected from C and N;

Z² is selected from NR^1′, O, S and C;

R¹, R^1′ and R² are independently selected from H, C_1-8 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, and a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^a;

R^1a is independently selected from H, C_1-6 alkyl, —OH, —CN, —NO₂, (CH₂)_rC_3-6 cycloalkyl, and a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^a;

R^a, at each occurrence, is selected from C_1-4 alkyl, C_2-3 alkenyl, C_2-8 alkynyl, (CHR′)_rC_3-6 cycloalkyl, Cl, Br, I, F, (CF₂)_rCF₃, NO₂, CN, (CHR′)_rNR^bR^b, (CHR′)_rOH, (CHR′)_rOR^c, (CHR′)_rSH, (CHR′)_rSR^c, (CHR′)_rC(O)R^b, (CHR′)_rC(O)NR^bR^b, (CHR′)_rNR^bC(O)R^b, (CHR′)_rC(O)OR^b, (CHR′)_rOC(O)R^c, (CHR′)_rCH(═NR^b)NR^bR^b, (CHR′)_rNHC(═NR^bC(O)NR^bR^b, (CHR′)_rS(O)_pR^c, (CHR′)_rS(O)₂NR^bR^b, (CHR′)_rNR^bS(O)₂R^c, and (CHR′)_rphenyl;

R^b, at each occurrence, is selected from H, C_1-6 alkyl, C_3-6 cycloalkyl, and phenyl;

R^c, at each occurrence, is selected from C_1-6 alkyl, C_3-6 cycloalkyl, and phenyl;

alternatively, R¹ and R² join to form a 5, 6, or 7-membered ring substituted with 0-3 R^a;

R³ is selected from a (CR^3′R^3″)_r—C_3-10 carbocyclic residue substituted with 0-5 R¹⁵ and a (CR^3′R^3″)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R¹⁵;

R^3′ and R^3″, at each occurrence, are selected from H, C_1-6 alkyl, (CH₂)_rC_3-6 cycloalkyl, and phenyl;

R⁴ is absent, taken with the nitrogen to which it is attached to form an N-oxide, or selected from C_1-8 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, (CH₂)_qC(O)R^4b, (CH₂)_qC(O)NR^4aR^4a′, (CH₂)_qC(O)OR^4a, and a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-3 R^4c;

R^4a and R^4a′, at each occurrence, are selected from H, C_1-6 alkyl, (CH₂)_rC_3-6 cycloalkyl, and phenyl;

R^4b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, (CH₂)_rC_3-6 cycloalkyl, C_2-8 alkynyl, and phenyl;

R^4c, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, C_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, (CH₂)_rOH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^4aR^4a′, and (CH₂)_rphenyl;

R⁷, is selected from H, C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CHR′)_qOH, (CHR′)_qSH, (CHR′)_qOR^7d, (CHR′)_qSR^7d, (CH₂CHR′)_qNR^7aR^7a′, (CHR′)_rC(O)OH, (CHR′)_rC(O)R^7b, (CHR′)_rC(O)NR^7aR^7a′, (CHR′)_qNR^7aC(O)R^7b, (CHR′)_qNR^7aC(O)H, (CHR′)_rC(O)OR^7a, (CHR′)_qOC(O)R^7b, (CHR′)_qS(O)_pR^7b, (CHR′)_qS(O)₂NR^7aR^7a′, (CHR′)_qNR^7aS(O)₂R^7b, (CHR′)_qNHC(O)NR^7aR^7a′, (CHR′)_qNHC(O)OR^7a, (CHR′)_qOC(O)NR^7aR^7a′, C_1-6 haloalkyl, a (CHR′)_r—C_3-10 carbocyclic residue substituted with 0-3 R^7c, and a (CHR′)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^7c;

R^7a and R^7a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^7e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^7e;

R^7b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_r—C_3-6 carbocyclic residue substituted with 0-2 R^7e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^7e;

R^7c, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, (CF₂)_rCF₃, NO₂, CN, (CH₂)_rNR^7fR^7f, (CH₂)_rOH, (CH₂)_rOC_1-4 alkyl, (CH₂)_rSC_1-4 alkyl, (CH₂)_rC(O)OH, (CH₂)_rC(O)R^7b, (CH₂)_rC(O)NR^7fR^7f, (CH₂)_rNR^7fC(O)R^7b, (CH₂)_rC(O)OC_1-4 alkyl, (CH₂)_rOC(O)R_7b, (CH₂)_rC(═NR^7f)NR^7fR^7f, (CH₂)_rS(O)_pR^7b, (CH₂)_rNHC(═NR^7f)NR^7fR^7f, (CH₂)_rS(O)₂NR^7fR^7f, (CH₂)_rNR^7fS(O)₂R^7b, and (CH₂)_rphenyl substituted with 0-3 R^7e;

R^7d, at each occurrence, is selected from methyl, CF₃, C_2-6 alkyl substituted with 0-3 R^7e, C_3-6 alkenyl, C_3-6 alkynyl, and a C_3-10 carbocyclic residue substituted with 0-3 R^7c;

R^7e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, C_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^7fR^7f, and (CH₂)_rphenyl;

R^7f, at each occurrence, is selected from H, C_1-6 alkyl, and C_3-6 cycloalkyl;

R⁸ is selected from H, C_1-6 alkyl, C_3-6 cycloalkyl, and (CH₂)_rphenyl substituted with 0-3 R^8a;

R^8a, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, C_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^7fR^7f, and (CH₂)_rphenyl;

alternatively, R⁷ and R⁸ join to form C_3-7 cycloalkyl, ═NR^8b, or ═O;

R^8b is selected from H, C_1-6 alkyl, C_3-6 cycloalkyl, OH, CN, and (CH₂)_r-phenyl;

R⁹, is selected from H, C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, F, Cl, Br, I, NO₂, CN, (CHR′)_rOH, (CHR′)_rSH, (CHR′)_rOR^9d, (CHR′)_rSR^9d, (CHR′)_rNR^9aR^9a′, (CHR′)_rC(O)OH, (CHR′)_rC(O)R^9b, (CHR′)_rC(O)NR^9aR^9a′, (CHR′)_rNR^9aC(O)R^9b, (CHR′)_rNR^9aC(O)H, (CHR′)_rNR^9aC(O)NR^9aR^9a, (CHR′)_rC(O)OR^9a, (CHR′)_rOC(O)R^9b, (CHR′)_rS(O)_pR^9b, (CHR′)_rS(O)₂NR^9aR^9a′, (CHR′)_rNR^9aS(O)₂R^9b, C_1-6 haloalkyl, a (CHR′)_r—C_3-10 carbocyclic residue substituted with 0-5 R^9c, and a (CHR′)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^9c;

R^9a and R^9a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^9e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^9e;

R^9b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_r—C_3-6 carbocyclic residue substituted with 0-2 R^9e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^9e;

R^9c, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, (CF₂)_rCF₃, NO₂, CN, (CH₂)_rNR^9fR^9f, (CH₂)_rOH, (CH₂)_rOC_1-4 alkyl, (CH₂)_rSC_1-4 alkyl, (CH₂)_rC(O)OH, (CH₂)_rC(O)R^9b, (CH₂)_rC(O)NR^9fR^9f, (CH₂)_rNR^9fC(O)R^9b, (CH₂)_rC(O)OC_1-4 alkyl, (CH₂)_rOC(O)R^9b, (CH₂)_rC(═NR^9f)NR^9fR^9f(CH₂)_rS(O)_pR^9b, (CH₂)_rNHC(═NR^9f)NR^9fR^9f, (CH₂)_rS(O)₂NR^9fR^9f, (CH₂)_rNR^9fS(O)₂R^9b, and (CH₂)_rphenyl substituted with 0-3 R^9e;

R^9d, at each occurrence, is selected from methyl, CF₃, C_2-6 alkyl substituted with 0-3 R^9e, C_3-6 alkenyl, C_3-6 alkynyl, a C_3-10 carbocyclic residue substituted with 0-3 R^9c, and a 5-6 membered heterocyclic system containing 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R^9c;

R^9e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^9fR^9f, and (CH₂)_rphenyl;

R^9f, at each occurrence, is selected from H, C_1-6 alkyl, and C_3-6 cycloalkyl;

R¹⁰, is selected from H, C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, F, Cl, Br, I, NO₂, CN, (CH₂)_rOH, (CH₂)_rOR^10d, (CH₂)_rSR^10d, (CH₂)_rNR^10aR^10a′, (CH₂)_rC(O)OH, (CH₂)_rC(O)R^10b, (CH₂)_rC(O)NR^10aR^10a′, (CH₂)_rNR^10aC(O)R^10a, (CH₂)_rNR^10aC(O)H, (CH₂)_rC(O)OR^10a, (CH₂)_rOC(O)R^10b, (CH₂)_rS(O)_pR^10b, (CH₂)_rS(O)₂NR^10aR^10a′, (CH₂)_rNR^10aS(O)₂R^10b, C_1-6 haloalkyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^10c, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^10c;

R^10a and R^10a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^10e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^10e;

R^10b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_r—C_3-6 carbocyclic residue substituted with 0-2 R^10e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^10e;

R^10c, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, (CF₂)_rCF₃, NO₂, CN, (CH₂)_rNR^10fR^10f, (CH₂)_rOH, (CH₂)_rOC_1-4 alkyl, (CH₂)_rSC_1-4 alkyl, (CH₂)_rC(O)OH, (CH₂)_rC(O)R^10b, (CH₂)_rC(O)NR^10fR^10f, (CH₂)_rNR^10fC(O)R^10a, (CH₂)_rC(O)OC_1-4 alkyl, (CH₂)_rOC(O)R_10b, (CH₂)_rC(═NR^10f)NR^10fR^10f, (CH₂)_rS(O)_pR^10b, (CH₂)_rNHC(═NR^10f)NR^10fR^10f, (CH₂)_rS(O)₂NR^10fR^10f, (CH₂)_rNR^10fS(O)₂R^10b, and (CH₂)_rphenyl substituted with 0-3 R^10e;

R^10d, at each occurrence, is selected from methyl, CF₃, C_2-6 alkyl substituted with 0-3 R^10e, C_3-6 alkenyl, C_3-6 alkynyl, a C_3-10 carbocyclic residue substituted with 0-3 R^10c, and a 5-6 membered heterocyclic system containing 1-4 heteroatoms selected from the group consisting of N, O, and S substituted with 0-3 R^10c;

R^10e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^10fR^10f, and (CH₂)_rphenyl;

R^10f, at each occurrence, is selected from H, C_1-6 alkyl, and C_3-6 cycloalkyl;

alternatively, R⁹ and R¹⁰ join to form C_3-4 cycloalkyl, 5-6-membered cyclic ketal, or ═O;

with the proviso that when R¹⁰ is —OH, R⁹ is not halogen, cyano, or bonded to the carbon to which it is attached through a heteroatom;

R¹¹, is selected from H, C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_qOH, (CH₂)_qSH, (CH₂)_qOR^11d, (CH₂)_qSR^11d, (CH₂)_qNR^11aR^11a′, (CH₂)_rC(O)OH, (CH₂)_rC(O)R^11b, (CH₂)_rC(O)NR^11aR^11a′, (CH₂)_qNR^11aC(O)R^11b, (CH₂)_qNR^11aC(O)NR^11aR^11a, (CH₂)_rC(O)OR^11a, (CH₂)_qOC(O)R^11b, (CH₂)_qS(O)_pR^11b, (CH₂)_qS(O)₂NR^11aR^11a′, (CH₂)_qNR^11aS(O)₂R^11b, C_1-6 haloalkyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^11c, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^11c;

R^11a and R^11a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^11e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^11e;

R^11b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_r—C_3-6 carbocyclic residue substituted with 0-2 R^11e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^11e;

R^11c, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, (CF₂)_rCF₃, NO₂, CN, (CH₂)_rNR^11fR^11f, (CH₂)_rOH, (CH₂)_rOC_1-4 alkyl, (CH₂)_rSC_1-4 alkyl, (CH₂)_rC(O)OH, (CH₂)_rC(O)R_11b, (CH₂)_rC(O)NR^11fR^11f, (CH₂)_rNR^11fC(O)R^11a, (CH₂)_rC(O)OC_1-4 alkyl, (CH₂)_rOC(O)R^11b, (CH₂)_rC(═NR^11f)NR^11fR^11f, (CH₂)_rNHC(═NR^11f)NR^11fCR^11f, (CH₂)_rS(O)_pR^11b, (CH₂)_rS(O)₂NR^11fR^11f, (CH₂)_rN^11fS(O)₂R^11b, and (CH₂)_rphenyl substituted with 0-3 R^11e;

R^11d, at each occurrence, is selected from methyl, CF₃, C_2-6 alkyl substituted with 0-3 R^11e, C_3-6 alkenyl, C_3-6 alkynyl, and a C_3-10 carbocyclic residue substituted with 0-3 R^11c;

R^11e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, C_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^11fR^11f, and (CH₂)_rphenyl;

R^11f, at each occurrence, is selected from H, C_1-6 alkyl, and C_3-6 cycloalkyl;

R¹² is selected from H, C_1-6 alkyl, (CH₂)_qOH, (CH₂)_rC_3-6 cycloalkyl, and (CH₂)_tphenyl substituted with 0-3 R^12a;

R^12a, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, C_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^9fR^9f, and (CH₂)_rphenyl;

alternatively, R¹¹ and R¹² join to form C_3-7 cycloalkyl;

R¹⁴ is selected from C_1-4 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, C(O)NR^14aR^14a′, C(O)R^14b, C(O)OC_1-4 alkyl, (CH₂)_rS(O)_pR^14b, (CH₂)_rphenyl substituted with 0-3 R^14c, OR^14a, NR^14aR^14a′, ═O, and NR^14aC(O)R^14a′;

R^14a and R^14a′, at each occurrence, are selected from H, C_1-6 alkyl, (CH₂)_rC_3-6 cycloalkyl, and (CH₂)_rphenyl substituted with 0-3 R^14c, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^14c;

R^14b, at each occurrence, is selected from C_1-6 alkyl, (CH₂)_rC_3-6 cycloalkyl, and (CH₂)_rphenyl substituted with 0-3 R^14c, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^14c; and

R^14c, at each occurrence, is selected from C_1-6 alkyl, (CH₂)_rC_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, (CH₂)_wphenyl;

R¹⁵, at each occurrence, is selected from C_1-8 alkyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, NO₂, CN, (CHR′)_rNR^15aR^15a′, (CHR′)_rOH, (CHR′)_rO(CHR′)_rR^15d, (CHR′)_rSH, (CHR′)_rC(O)H, (CHR′)_rS(CHR′)_rR^15d, (CHR′)_rC(O)OH, (CHR′)_rC(O)(CHR′)_rR^15b, (CHR′)_rC(O)NR^15aR^15a′, (CHR′)_rNR^15fC(O)(CHR′)_rR^15b, (CHR′)_rNR^15fC(O)NR^15aR^15a′, (CHR′)_rC(O)O(CHR′)_rR^15d, (CHR′)_rOC(O)(CHR′)_rR^15b, (CHR′)_rC(═NR^15f)NR^15aR^15a′, (CHR′)_rNHC(═NR^15f)NR^15aR^15a′, (CHR′)_rS(O)_p(CHR′)_rR^15b, (CHR′)_rS(O)₂NR^15aR^15a′, (CHR′)_rNR^15fS(O)₂(CHR′)_rR^15b, C_1-6 haloalkyl, C_2-8 alkenyl substituted with 0-3 R′, C_2-8 alkynyl substituted with 0-3 R′, (CHR′)_rphenyl substituted with 0-3 R^15e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^15e;

R′, at each occurrence, is selected from H, C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, and (CH₂)_rphenyl substituted with R^15e;

R^15a and R^15a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^15e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^15e;

R^15b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_r—C_3-6 carbocyclic residue substituted with 0-3 R^15e, and (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^15e;

R^15d, at each occurrence, is selected from C_3-8 alkenyl, C_3-8 alkynyl, methyl, CF₃, C_2-6 alkyl substituted with 0-3 R^15e, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-3 R^15e, and a (CH₂)_r5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^15e;

R^15e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^15fR^15f, and (CH₂)_rphenyl;

R^15f, at each occurrence, is selected from H, C_1-6 alkyl, C_3-6 cycloalkyl, and phenyl;

R¹⁶, at each occurrence, is selected from C_1-8 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, NO₂, CN, (CHR′)_rNR^16aR^16a′, (CHR′)_rOH, (CHR′)_rO(CHR′)_rR^16d, (CHR′)_rSH, (CHR′)_rC(O)H, (CHR′)_rS(CHR′)_rR^16d, (CHR′)_rC(O)OH, (CHR′)_rC(O)(CHR′)_rR^16b, (CHR′)_rC(O)NR^16aR^16a′, (CHR′)_rNR^16fC(O)(CHR′)_rR^16b, (CHR′)_rC(O)O(CHR′)_rR^16d, (CHR′)_rOC(O)(CHR′)_rR^16b, (CHR′)_rC(═NR^16f)NR^16aR^16a′, (CHR′)_rNHC(═NR^16f)NR^16aR^16a′, (CHR′)_rS(O)_p(CHR′)_rR^16b, (CHR′)_rS(O)₂NR^16aR^16a′, (CHR′)_rNR^16fS(O)₂(CHR′)_rR^16b, C_1-6 haloalkyl, C_2-8 alkenyl substituted with 0-3 R′, C_2-8 alkynyl substituted with 0-3 R′, and (CHR′)_rphenyl substituted with 0-3 R^16e;

R^16a and R^16a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-6 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^16e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^16e;

R^16b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_rC_3-6 carbocyclic residue substituted with 0-3 R^16e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^16e;

R^16d, at each occurrence, is selected from C_3-8 alkenyl, C_3-8 alkynyl, methyl, CF₃, C_2-6 alkyl substituted with 0-3 R^16e, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-3 R^16e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^16e;

R^16e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^16fR^16f, and (CH₂)_rphenyl;

R^16f, at each occurrence, is selected from H, C_1-5 alkyl, and C_3-6 cycloalkyl, and phenyl;

R¹⁷, is selected from H, C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CHR′)_rOH, (CHR′)_rSH, (CHR′)_rOR^17d, (CHR′)_rSR^17d, (CHR′)_rNR^17aR^17a′, (CHR′)_rC(O)OH, (CHR′)_rC(O)R^17b, (CHR′)_rC(O)NR^17aR^17a′, (CHR′)_rNR^17aC(O)R^17b, (CHR′)_rNR^17aC(O)H, (CHR′)_rC(O)OR^17a, (CHR′)_rOC(O)R^17b, (CHR′)_rS(O)_pR^17b, (CHR′)_rS(O)₂NR^17aR^17a′, (CHR′)_rNR^17aS(O)₂R^17b, C_1-6 haloalkyl, a (CHR′)_r—C_3-10 carbocyclic residue substituted with 0-3 R^17c, and a (CHR′)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^17c;

R^17a and R^17a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^17e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^17e;

R^17b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_r—C_3-6 carbocyclic residue substituted with 0-2 R^17e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^17e;

R^17c, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, (CF₂)_rCF₃, NO₂, CN, (CH₂)_rNR^17fR^17f, (CH₂)_rOH, (CH₂)_rOC_1-4 alkyl, (CH₂)_rSC_1-4 alkyl, (CH₂)_rC(O)OH, (CH₂)_rC(O)R^17b, (CH₂)_rC(O)NR^17fR^17f, (CH₂)_rNR^17fC(O)R^17a, (CH₂)_rC(O)OC_1-4 alkyl, (CH₂)_rOC(O)R^17b, (CH₂)_rC(═NR^17f)NR^17fR^17f, (CH₂)_rS(O)_pR^17b, (CH₂)_rNHC(═NR^17f)NR^17fR^17f, (CH₂)_rS(O)₂NR^17fR^17f, (CH₂)_rNR^17fS(O)₂R^17b, and (CH₂)_rphenyl substituted with 0-3 R^17e;

R^17d, at each occurrence, is selected from methyl, CF₃, C_1-6 alkyl substituted with 0-3 R^17e, C_3-6 alkenyl, C_3-6 alkynyl, and a C_3-10 carbocyclic residue substituted with 0-3 R^17c;

R^17e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, C_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^17fR^17f, and (CH₂)_rphenyl;

R^17f, at each occurrence, is selected from H, C_1-6 alkyl, and C_3-6 cycloalkyl;

R¹⁸, is selected from H, C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CHR′)_qOH, (CHR′)_qSH, (CHR′)_qOR^18d, (CHR′)_qSR^18d, (CHR′)_qNR^18aR^18a′, (CHR′)_rC(O)OH, (CHR′)_rC(O)R^18b, (CHR′)_rC(O)NR^18aR^18a′, (CHR′)_qNR^18aC(O)R^18b, (CHR′)_qNR^18aC(O)H, (CHR′)_rC(O)OR^18a, (CHR′)_qOC(O)R^18b, (CHR′)_qS(O)_pR^18b, (CHR′)_qS(O)₂NR^18aR^18a′, (CHR′)_qNR^18aS(O)₂R^18b, C_1-6 haloalkyl, a (CHR′)_r—C_3-10 carbocyclic residue substituted with 0-3 R^18c, and a (CHR′)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-2 R^18c;

R^18a and R^18a′, at each occurrence, are selected from H, C_1-6 alkyl, C_3-8 alkenyl, C_3-8 alkynyl, a (CH₂)_r—C_3-10 carbocyclic residue substituted with 0-5 R^18e, and a (CH₂)_r-5-10 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^18e;

R^18b, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, a (CH₂)_r—C_3-6 carbocyclic residue substituted with 0-2 R^18e, and a (CH₂)_r-5-6 membered heterocyclic system containing 1-4 heteroatoms selected from N, O, and S, substituted with 0-3 R^18e;

R^18c, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, (CH₂)_rC_3-6 cycloalkyl, Cl, Br, I, F, (CF₂)_rCF₃, NO₂, CN, (CH₂)_rNR^18fR^18f, (CH₂)_rOH, (CH₂)_rOC_1-4 alkyl, (CH₂)_rSC_1-4 alkyl, (CH₂)_rC(O)OH, (CH₂)_rC(O)R^18b, (CH₂)_rC(O)NR^18fR^18f, (CH₂)_rNR^18fC(O)R^18b, (CH₂)_rC(O)OC_1-4 alkyl, (CH₂)_rOC(O)R^18b, (CH₂)_rC(═NR^18f)NR^18fR^18f, (CH₂)_rS(O)_pR^18b, (CH₂)_rNHC(═NR^18f)NR^18fR^18f, (CH₂)_rS(O)₂NR^18fR^18f, (CH₂)_rNR^18fS(O)₂R^18b, and (CH₂)_rphenyl substituted with 0-3 R^18e;

R^18d, at each occurrence, is selected from methyl, CF₃, C_1-6 alkyl substituted with 0-3 R^18e, C_3-6 alkenyl, C_3-6 alkynyl, and a C_3-10 carbocyclic residue substituted with 0-3 R^18c;

R^18e, at each occurrence, is selected from C_1-6 alkyl, C_2-8 alkenyl, C_2-8 alkynyl, C_3-6 cycloalkyl, Cl, F, Br, I, CN, NO₂, (CF₂)_rCF₃, (CH₂)_rOC_1-5 alkyl, OH, SH, (CH₂)_rSC_1-5 alkyl, (CH₂)_rNR^18fR^18f, and (CH₂)_rphenyl;

R^18f, at each occurrence, is selected from H, C_1-6 alkyl, and C_3-6 cycloalkyl;

g is selected from 0, 1, 2 and 3;

h is selected from 0 and 1;

i is selected from 1, 2, 3, 4, and 5;

j is selected from 0, 1, 2, 3, 4, and 5;

k is selected from 0, 1, and 2;

l is selected from 0, 1, 2 and 3, wherein 1+h equals 2 or 3;

v, at each occurrence, is independently selected from 0, 1, and 2;

t, at each occurrence, is selected from 1 and 2;

w, at each occurrence, is selected from 0 and 1;

r, at each occurrence, is selected from 0, 1, 2, 3, 4, and 5;

s, at each occurrence, is selected from 0, 1, 2, 3, 4, and 5;

q, at each occurrence, is selected from 1, 2, 3, 4, and 5; and

p, at each occurrence, is selected from 1 and 2.