Y¹ is CH or N;

Q¹ is —OH;

Q² and Q³ independently selected from the group consisting of

(1) hydrogen, and

(2) halogen;

R^a is hydrogen;

R^b is selected from the group consisting of

(1) hydrogen, and

(2) —C_1-10 alkyl,

(3) —(CH₂)_n—NR^cR^d wherein R^c and R^d are selected from the group consisting of hydrogen and C_1-10 alkyl, and n is 2, 3 or 4, and

(4) —(CH₂)_n′—O—R^e, wherein R^e is selected from the group consisting of

(a) C_1-10 alkyl,

(b) —C_0-3 alkyl-aryl, wherein said aryl is selected from the group consisting of phenyl and naphthyl,

wherein said alkyl and aryl are unsubstituted or substituted with one or more

(i) halo,

(ii) —OH,

(iii) —CN,

(iv) —O—C_1-10 alkyl,

and n′ is 1, 2, 3 or 4;

m is 1 or 2;

R¹ is

(1) aryl selected from the group consisting of phenyl and napthyl, or

(2) heteroaryl selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl,

(3) —C_1-10 alkyl, and

(4) —C_3-8 cycloalkyl,

wherein said aryl, heteroaryl, alkyl and cycloalkyl is unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN,

(d) —O—C_1-10 alkyl,

(e) —C_1-10 alkyl,

(f) —C_3-8 cycloalkyl,

(g) aryl selected from the group consisting of phenyl and napthyl, or

(h) heteroaryl selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimnidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl;

R² is selected from the group consisting of:

(1) (R⁴—SO₂)N(R⁷)—, wherein R⁴ is

(a) —C_1-10 alkyl,

(b) —C_3-8 cycloalkyl,

wherein said alkyl and cycloalkyl is unsubstituted or substituted with one or more

(i) halo,

(ii) —OH,

(iii) —CN,

(iv) —O—C_1-10 alkyl,

(v) —C_1-10 alkyl,

(vi) —C_3-8 cycloalkyl,

(vii) aryl selected from the group consisting of phenyl and napthyl, or

(viii) heteroaryl selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl;

and said aryl and heteroaryl is unsubstituted or substituted with one or more

(A) halo,

(B) —OH,

(C) —CN,

(D) —O—C_1-10 alkyl,

(E) —C_3-8 cycloalkyl, or

(F) —C_1-10 alkyl,

(c) heteroaryl selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl,

wherein said heteroaryl is unsubstituted or substituted with one or more

(i) halo,

(ii) —OH,

(iii) —CN,

(iv) —O—C_1-10 alkyl,

(v) —C_3-8 cycloalkyl, or

(vi) —C_1-10 alkyl,

(d) —CH₂)_x—NR^fR^g wherein R^f and R^g are selected from the group consisting of hydrogen and C_1-10 alkyl, and x is 0, 1, 2, 3 or 4, or R^f and R^g, together with the nitrogen atom to which they are attached form the group

wherein y is 1 or 2, Y⁵ is —CHR²¹, —O— or NR²¹, wherein R²¹ is selected from the group consisting of;

(i) hydrogen, and

(ii) C_1-10 alkyl,

wherein said alkyl is unsubstituted or substituted with one or more

(A) halo,

(B) —OH,

(C) —CN,

(D) —O—C_1-10 alkyl, or

(E) —C_3-8 cycloalkyl;

R⁷ is selected from the group consisting of

(a) hydrogen, and

(b) —C_1-10 alkyl,

(c) aryl selected from the group consisting of phenyl and napthyl, or

(d) heteroaryl selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl

wherein said alkyl, aryl and heteroaryl is unsubstituted or substituted with one or more

(i) halo,

(ii) —OH,

(iii) —CN,

(iv) —O—C_1-10 alkyl,

(v) —C_3-8 cycloalkyl,

(vi) aryl selected from the group consisting of phenyl and napthyl, or

(vii) heteroaryl selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl,

wherein said cycloalkyl, aryl or heteroaryl is unsubstituted or substituted with one or more

(A) halo,

(B) —OH,

(C) —CN,

(D) —O—C_1-10 alkyl,

(E) —C_3-8 cycloalkyl, or

(F) aryl selected from the group consisting of phenyl and napthyl;

(e) —(CH₂)_y′—NR^hRⁱ wherein R^h and Rⁱ are selected from the group consisting of hydrogen and C_1-10 alkyl, and y′ is 1, 2, 3 or 4, or or R^h and Rⁱ, together with the nitrogen atom to which they are attached from the group

wherein y′ is 1 or 2, Y⁶ is —CHR²², —O— or NR²², wherein R²² is selected from the group consisting of;

(i) hydrogen, and

(ii) C_1-10 alkyl,

wherein said alkyl is unsubstituted or substituted with one or more

(A) halo,

(B) —OH,

(C) —CN,

(D) —O—C_1-10 alkyl, or

(E) —C_3-8 cycloalkyl,

or R⁴ and R⁷ are linked together to form the group

wherein z is 1, 2 or 3; or

wherein z is 1, 2 or 3

wherein R⁸ is selected from the group consisting of

(a) —CN,

(b) hydrogen, and

(c) tetrazolyl;

wherein o is 1, 2, 3 or 4; and

wherein Y² is —NH═CH— or —CH═NH—;

R³ is selected from the group consisting of

wherein Y³ is CR^6c or N;

R⁵ is C_1-10 alkyl or C_1-2 perfluoroalkyl;

R^6a, R^6b, and R^6c are independently selected from the group consisting of:

(1) hydrogen,

(2) halo,

(3) —C_1-10 alkyl,

(4) —OH,

(5) —CN,

(6) —C_3-8 cycloalkyl, and

(7) —O—C_1-10 alkyl;

R⁹ and R¹⁰ are independently selected from the group consisting of

(1) hydrogen,

(2) —C_1-10 alkyl, and

(3) —C_3-8 cycloalkyl,

wherein said alkyl and cycloalkyl are unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN,

(d) —O—C_1-10 alkyl,

(e) —C_3-8 cycloalkyl, and

(f) —NR^jR^k wherein R^j and R^k are C_1-10 alkyl;

or R⁹ and R¹⁰ are joined together with the nitrogen atom to which they are attached to form

wherein w is 1, 2 or 3, and

R²³ is selected from the group consisting of

(a) hydrogen,

(b) —C_1-10 alkyl,

(c) —C_3-8 cycloalkyl,

(d) —C_2-10 alkenyl,

(e) —C_2-10 alkynyl,

(f) —(CH₂)_p-phenyl,

(g) —(CH₂)_p-heteroaryl, wherein said heteroaryl is selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl,

wherein p is 0 or 1, and

wherein said alkyl, alkenyl, alkynyl, cycloalkyl, phenyl and heteroaryl is unsubstituted or substituted with one or more

(i) halo,

(ii) —C_1-10 alkyl,

(iii) —OH,

(iv) —CN,

(v) —C_3-8 cycloalkyl, or

(vi) —O—C_1-10 alkyl;

R¹¹ is selected from the group consisting of

(1) —CH—

(2) —CH₂—,

(3) —O—, and

(4) —NR¹⁷—,

provided that when R¹¹ is —CH— the dotted line forms a bond and when R¹¹ is —CH₂—, —O— or —NR¹⁷— the dotted line is absent;

R¹⁷ is hydrogen or C_1-10 alkyl, wherein said C_1-10 alkyl is unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN,

(d) —C_3-8 cycloalkyl,

(e) —O—C_1-10 alkyl,

(f) —(CH₂)_q-phenyl, wherein q is 1 or 2, and

(g) —NR¹⁸R¹⁹, and

wherein R¹⁸ and R¹⁹ are independently selected from the group consisting of

(i) hydrogen, or

(ii) C_1-10 alkyl;

or R¹⁸ and R¹⁹, together with the nitrogen atom to which they are attached, form the group

wherein q′ is 1 or 2, Y⁷ is —CHR²⁴, —O— or NR²⁴, wherein R²⁴ is selected from the group consisting of;

(a) hydrogen, and

(b) C_1-10 alkyl,

wherein said alkyl is unsubstituted or substituted with one or more

(i) halo,

(ii) —OH,

(iii) —CN,

(iv) —O—C_1-10 alkyl, or

(v) —C_3-8 cycloalkyl;

R²⁶ is selected from the group consisting of

(1) hydrogen,

(2) —C_1-3 alkyl;

R¹² is selected from the group consisting of

(1) hydrogen,

(2) —C_1-10 alkyl, wherein said alkyl is unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN,

(d) —C_3-8 cycloalkyl,

(e) —O—C_1-10 alkyl, or

(f) —NH₂,

(3) halo,

(4) —C_3-8 cycloalkyl,

(5) aryl selected from the group consisting of phenyl and napthyl, and

(6) heteroaryl selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl,

wherein said aryl and heteroaryl is unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN,

(d) —O—C_1-10 alkyl,

(e) —C_3-8 cycloalkyl, or

(f) —C_1-10 alkyl;

R¹³ is selected from the group consisting of

(1) hydrogen,

(2) C_1-10 alkyl, and

(3) —C_3-8 cycloalkyl;

wherein said alkyl and cycloalkyl is unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN,

(d) —C_3-8 cycloalkyl,

(e) —O—C_1-10 alkyl, and

(f) —C_1-10 alkyl;

R¹⁴ is selected from the group consisting of

(1) —C_1-10 alkyl, and

(2) —C_3-8 cycloalkyl;

wherein said alkyl and cycloalkyl is unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN

(d) —C_3-8 cycloalkyl,

(e) —O—C_1-10 alkyl, or

(f) —C_1-10 alkyl;

(3) —(CH₂)_v—NR¹⁵R¹⁶, wherein v is 2, 3 or 4, and

wherein R¹⁵ and R¹⁶ are independently selected from the group consisting of

a) hydrogen, or

b) C_1-10 alkyl, wherein said C_1-10 alkyl is unsubstituted or substituted with one or more

(i) halo,

(ii) —OH,

(iii) —CN,

(iv) —C_3-8 cycloalkyl, or

(v) —O—C_1-10 alkyl;

or R¹⁵ and R¹⁶, together with the nitrogen atom to which they are attached, form the group

wherein s is 1 or 2, Y⁴ is —CHR²⁴—, —O— or —NR²⁴—, wherein R²⁴ is selected from the group consisting of

(i) hydrogen, and

(ii) C_1-10 alkyl,

wherein said alkyl is unsubstituted or substituted with one or more

(A) halo,

(B) —OH,

(C) —CN,

(D) —O—C_1-10 alkyl, or

(E) —C_3-8 cycloalkyl,

(4) —(CH₂)_r-phenyl, wherein r is 1, 2, 3, or 4, and

wherein said phenyl is unsubstituted or substituted with one or more

(a) halo,

(b) —OH,

(c) —CN,

(d) —O—C_1-10 alkyl,

(e) —C_3-8 cycloalkyl, or

(f) —C_1-10 alkyl;

or R¹³ and R¹⁴, together with the nitrogen atom to which they are attached, form the group

wherein u is 1 or 2, Y⁸ is —CHR²⁵—, —O— or —NR²⁵—, wherein R²⁵ is selected from the group consisting of

(a) hydrogen,

(b) C_1-10 alkyl,

(c) —(CH₂)_t-phenyl,

(d) —(CH₂)_t-heteroaryl, wherein said heteroaryl is selected from the group consisting of pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, tetrazolyl, furanyl, imidazolyl, triazinyl, pyranyl, thiazolyl, thienyl, thiophenyl, triazolyl, oxazolyl, isoxazolyl, thiazolyl, oxadiazolyl, indolyl, quinolinyl, isoquinolinyl, benzimidazolyl and benzoxazolyl,

wherein t is 0 or 1, and

wherein said alkyl, phenyl and heteroaryl is unsubstituted or substituted with one or more

(i) halo,

(ii) —C_1-10 alkyl,

(iii) —OH,

(iv) —CN,

(v) —C_3-8 cycloalkyl, or

(vi) —O—C_1-10 alkyl;