Y is carbonyl, sulfonyl, or a bond;

A is N;

n is 1;

k is 0 and the bridging bonds are absent;

x is 0, 1 or 2;

each R₃ is independently hydrogen, C₁-C₆alkyl, or

 wherein w is 1, 2, or 3;

R is selected from the group consisting of (b) and (d):

wherein

each Q, and V is independently hydrogen, C₁-C₆alkyl,

C₁-C₆alkoxy, halogen, trifluoromethyl or —CH₂OC₁-C₆alkyl;

p is 0, 1 or 2;

J is hydrogen,

 wherein each R₇₃ is independently hydrogen, C₁-C₆alkyl, halogen or trifluoromethyl and p is as hereinbefore defined;

—B— represents a group selected from groups (a) through (m):

 (a) —(CH₂)_z— wherein z is 2, 3, 4, 5, 6 or 7;

wherein

R₅ and R₆ are each independently hydrogen or C₁-C₃ linear alkyl;

R₇ and R₈ are each independently hydrogen or

C₁-C₃linear alkyl with the proviso that when R₇ is

C₁-C₃linear alkyl, R₈ cannot be C₁-C₃linear alkyl;

 wherein j is 0 or 1;

 wherein j is defined as above;

 wherein j is defined as above;

 wherein j is defined as above;

 wherein a is 0 or 1;

R₁ is a) hydrogen;

b) saturated or unsaturated C₁-C₆alkyl which is optionally mono- or di-substituted with hydroxy; or

wherein

each G is independently hydrogen, C₁-C₆alkyl, halogen or trifluoromethyl;

each R₉ and R₁₀ is independently hydrogen or C₁-C₃alkyl;

t is 0 or 1; and

q is 0 or 1;

R₂ is a group selected from saturated or unsaturated C₁-C₁₀alkyl, trifluoromethyl or a group selected from (a)-(ss):

wherein

e is 3, 4 or 5;

y is 0, 1, or 2;

each R₁₁ and R₁₂ is independently hydrogen or C₁-C₃linear alkyl;

D is a group selected from (a) or (b):

(a) —(CR₁₃R₁₄)_u—

wherein each R₁₃ and R₁₄ is independently hydrogen, halogen or C₁-C₃linear alkyl; and

u is 0, 1, 2 or 3;

(b) —CR₁₅═CR₁₆—

wherein each R₁₅ and R₁₆ is independently hydrogen, C₁-C₃linear alkyl or amino;

o is 0, 1 or 2;

M is a group selected from:

(1) hydrogen;

(2) C₁-C₈alkyl;

(3) C₁-C₆alkoxy;

(4) hydroxy;

(5) trifluoromethyl;

(6) trifluoromethoxy;

(7) —NO₂;

(8) —CN;

(9) —SO₂CH₃;

(10) halogen;

 wherein each L is independently hydrogen or —NR₆₇R₆₈, wherein R₆₇ and R₆₈ are each independently hydrogen, C₁-C₆alkyl or

 C₁-C₆alkoxy and o is 0, 1 or 2 as hereinbefore defined;

 wherein T is hydrogen or halogen and r is 0, 1, or 2;

(17)

—NR₆₉R₇₀

 wherein R₆₉ and R₇₀ are each independently hydrogen or C₁-C₆alkyl:

(18)

—SO₂NH₂;

each R₁₇ and R₁₈ is independently hydrogen or C₁-C₃alkyl;

s is 0, 1 or 2;

R₅₃ is hydrogen, halogen, hydroxy, C₁-C₆alkyl, amino or C₁-C₃alkoxy;

R₅₄ is hydrogen, halogen, hydroxy, C₁-C₆alkyl, amino, —SO₂NH₂ or C₁-C₃alkoxy;

each R₁₉ and R₂₀ is independently hydrogen or C₁-C₃alkyl;

v is 0, 1 or 2;

X is O or S;

each R₂₁ and R₂₂ is independently hydrogen or C₁-C₃alkyl;

d is 0, 1 or 2;

R₂₃ is a group selected from (a)-(h):

(a) hydrogen;

(b) C₁-C₆alkyl;

(c) halogen;

(d) hydroxy;

(e) C₁-C₃alkoxy; and

 wherein R₂₄ is hydrogen or halogen;

R₅₅ is hydrogen or C₁-C₆alkyl;

each R₂₅ and R₂₆ is independently hydrogen or C₁-C₃alkyl;

f is 0, 1 or 2;

R₂₇ is a group selected from (a)-(e):

(a) hydrogen;

(b) C₁-C₆alkyl;

(c) halogen;

(d) —SCH₃; and

 wherein X₁ is O or S and R₂₈ is hydrogen or C₁-C₆alkyl;

j is 0 or 1 as hereinbefore defined;

each R₅₆, R₅₇ and R₅₈ is independently hydrogen or C₁-C₆alkyl;

W is CH₂, CH₂OH or C═O;

each R₂₉ and R₃₀ is independently hydrogen or C₁-C₃alkyl;

g is 0 or 1;

X₂ is O or S;

each R₃₁ is independently hydrogen, halogen, C₁-C₆alkyl, trifluoromethyl, trifluoromethoxy; C₁-C₆alkoxy, or —NR₇₁R₇₂ wherein R₇₁ and R₇₂ are each independently hydrogen or C₁-C₆alkyl;

o is 0, 1 or 2 as hereinbefore defined;

R₃₂ is hydrogen, halogen or C₁-C₆alkyl;

R₃₃ is hydrogen, halogen, hydroxy, C₁-C₆alkyl or C₁-C₃alkoxy;

R₃₄ is hydrogen, C₁-C₆alkyl or —CH₂CO₂C₁-C₆alkyl;

each R₃₅ and R₃₆ is independently hydrogen or C₁-C₃ linear alkyl;

h is 0 or 1;

R₃₇ is hydrogen or C₁-C₆alkyl;

R₄₁ is hydrogen, C₁-C₆alkyl, benzyl, acyl, tosyl, pyridyl or phenyl wherein said phenyl is optionally mono- or di-substituted with substituents independently selected from halogen, hydroxy, C₁-C₆alkyl, C₁-C₆alkoxy and C₁-C₆acyl;

R₅₉ and R₆₀ are hydrogen, methyl or phenyl which is optionally mono- or di-substituted with substituents independently selected from halogen, hydroxy, C₁-C₆alkyl, C₁-C₆alkoxy and C₁-C₆acyl;

R₄₂ is hydrogen, C₁-C₆alkyl, C₁-C₆alkoxy, halogen, trifluoromethyl or phenoxy;

R₄₃ is hydrogen, C₁-C₆alkyl or benzyl;

R₆₁ is hydrogen or C₁-C₆alkyl;

R₄₄ is hydrogen, hydroxy, C₁-C₆alkyl, phenyl or acyl;

R₃₈ is hydrogen, methyl or phenyl which is optionally mono- or di-substituted with substituents independently selected from halogen, hydroxy, C₁-C₆alkyl, C₁-C₆alkoxy and C₁-C₆acyl;

R₄₅ is hydrogen, C₁-C₆alkyl, S—C₁-C₆alkyl, halogen or phenyl which is optionally mono- or di-substituted with substituents independently selected from halogen, hydroxy, C₁-C₆alkyl, C₁-C₆alkoxy and C₁-C₆acyl;

R₄₆ is hydrogen or halogen;

R₆₂ is hydrogen, halogen or C₁-C₆alkyl;

R₄₇ is SMe, SOMe or SO₂Me;

R₄₈ is hydrogen, C₁-C₆alkyl, trifluoromethyl, pyridyl, thiophenyl or phenyl which is optionally mono- or di-substituted with substituents independently selected from halogen, hydroxy, C₁-C₆alkyl, C₁-C₆alkoxy and C₁-C₆acyl;

R₆₃ is hydrogen or C₁-C₆alkyl;

R₄₉ is methyl, trifluoromethyl, phenyl or —CH₂SPh;

R₅₀ is hydrogen, methyl, acyl or benzyl;

i is 0 or 1;

y is 0, 1 or 2 as hereinbefore defined;

p is 0, 1 or 2 as hereinbefore defined;

each R₇₄ is independently hydrogen, C₁-C₆alkyl, C₁-C₆alkoxy or halogen;

R₅₁ is hydrogen, hydroxy, methyl, methoxy, chlorine or —SC₁-C₆alkyl;

R₅₂ is hydrogen, phenyl or thiophene;

R₃₉ is hydrogen or C₁-C₆alkyl;

R₄₀ is hydrogen, C₁-C₆alkyl, phenyl or benzyl;

b is 1, 2, 3 or 4;

each R₆₄ and R₆₅ is independently hydrogen or C₁-C₃alkyl;

u is 0, 1, 2, or 3 as hereinbefore defined;

each R₆₆ is independently hydrogen, C₁-C₆alkyl, halogen or phenyl which is optionally mono- or di-substituted with halogen, C₁-C₆alkyl or trifluoromethyl;

R₇₅ is hydrogen, halogen, C₁-C₆alkyl or furanyl;

c is 1 or 2;

w is 1, 2 or 3 as hereinbefore defined;

R₇₆ is hydrogen or C₁-C₆alkyl;

each R₇₇ and R₇₈ is independently hydrogen or C₁-C₃alkyl;

each R₇₉ and R₈₀ is independently hydrogen or C₁-C₃alkyl;

R₈₁ is C₁-C₆alkyl or phenyl optionally substituted with halogen;

each R₈₂ and R₈₃ is independently hydrogen or C₁-C₃alkyl;

R₈₄ is hydrogen or C₁-C₆alkyl;

j is 0 or 1 as hereinbefore defined; and

each R₈₅ and R₈₆ is independently hydrogen or C₁-C₃alkyl and wherein a hydroxyl group or an amino group can be acylated with (C₄-C₁₈)alkanoyl group or a (C₄-C₁₈)alkoxycarbonyl group.