| US 7,550,456 B2 | ||
| Substituted aryl cycloalkanoyl derivatives and methods of their use | ||
| Eugene John Trybulski, Huntingdon Valley, Pa. (US); Joseph Peter Sabatucci, Collegeville, Pa. (US); An Thien Vu, Pottstown, Pa. (US); Stephen Todd Cohn, Spring, Tex. (US); Arthur Attilio Santilli, Havertown, Pa. (US); Lori Krim Gavrin, Philadelphia, Pa. (US); Fei Ye, Audubon, Pa. (US); and Paige Erin Mahaney, Pottstown, Pa. (US) | ||
| Assigned to Wyeth, Madison, N.J. (US) | ||
| Filed on Feb. 14, 2008, as Appl. No. 12/31,187. | ||
| Application 12/031187 is a division of application No. 10/963111, filed on Oct. 12, 2004, granted, now 7,365,076. | ||
| Claims priority of provisional application 60/510943, filed on Oct. 14, 2003. | ||
| Claims priority of provisional application 60/561301, filed on Apr. 12, 2004. | ||
| Claims priority of provisional application 60/569996, filed on May 11, 2004. | ||
| Prior Publication US 2008/0153826 A1, Jun. 26, 2008 | ||
| Int. Cl. A01N 43/62 (2006.01); C07D 243/08 (2006.01) | ||
| U.S. Cl. 514—218 [540/575] | 12 Claims |
1. A compound of formula I:
 W is H or OR9;
R1 is phenyl, naphthyl, heteroaryl, benzyloxy, phenoxy, naphthyloxy, phenylethoxy, phenoxyethoxy, naphthylmethoxy, naphthylethoxy,
phenylcarbonylamino, phenylaminocarbonyl, trifluoromethoxy, nitrile, alkenyl, alkynyl, sulfonyl, sulfonamido, alkanoyl, alkoxycarbonyl,
alkylaminocarbonyl, or amino;
where said phenyl, naphthyl, heteroaryl, benzyloxy, phenoxy, naphthyloxy, phenylethoxy, phenoxyethoxy, naphthylmethoxy, naphthylethoxy,
phenylcarbonylamino, and phenylaminocarbonyl are optionally substituted with one or more R2;
R2 is R1, H, or one to two substituents independently selected from OH, alkyl, alkoxy, halo, trifluoromethyl, alkanoyloxy, trifluoromethoxy,
nitrile, nitro, alkenyl, alkynyl, sulfonyl, or sulfonamido;
or two R2 together form methylenedioxy;
R5 is H, (C1-C6)alkyl, or trifluoromethyl;
R6 and R7 are, independently, (C1-C6)alkyl or (C3-C6)cycloalkyl;
or R6 and R7 can together form a ring of 4 to 8 carbon atoms;
where any carbon atom of said R6 and R7 may be optionally replaced with N, S, or O;
where R6 and R7 may be optionally substituted with R5 or OH;
where R6 and R7 can form a ring with 4 to 8 carbons fused onto a cycloalkyl ring of 4 to 6 carbon atoms;
R8 is H, (C1-C6)alkyl, hydroxy(C1-C6)alkyl, benzyl optionally substituted with benzyloxy or phenyloxy, naphthylmethyl optionally substituted with one or more
R1, phenyl(C2-C6)alkyl optionally substituted with one or more R1, heteroarylmethyl optionally substituted with R1, cycloalkyl, cycloalkenyl, cycloalkylmethyl where any carbon atom can be optionally replaced with N, S, or O and where said
cycloalkylmethyl can be optionally substituted with OH, CF3, halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy, cycloalkenylmethyl where any carbon atom can be optionally replaced with
N, S, or O and where said cycloalkenylmethyl can be optionally substituted with OH, CF3, halo, alkoxy, alkyl, benzyloxy, or alkanoyloxy;
or R5 and R8, together with the nitrogen atom to which R8 is attached, form a ring optionally substituted with R5;
R9 is H, (C1-C4)alkyl, or (C1-C4)alkyl-C(═O);
t is 1, 2, or 3;
and x is 2.
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