US 7,550,440 B2
Topical application of ivermectin for the treatment of dermatological conditions/afflictions
Vincent Manetta, Bordentown, N.J. (US); and Gary R. Watkins, Piscataway, N.J. (US)
Assigned to Galderma S.A., Cham (Switzerland)
Filed on Oct. 24, 2005, as Appl. No. 11/255,910.
Application 11/255910 is a continuation of application No. PCT/EP2004/004950, filed on Apr. 22, 2004.
Claims priority of provisional application 60/468994, filed on May 09, 2003.
Claims priority of application No. 03 05048 (FR), filed on Apr. 24, 2003.
Prior Publication US 2006/0100165 A1, May 11, 2006
Int. Cl. A61K 31/70 (2006.01)
U.S. Cl. 514—30 4 Claims
 
1. A regime or regimen for the treatment of rosacea, comprising topically applying onto the affected skin area of an individual in need of such treatment, the topical pharmaceutical emulsion which comprises:
   
  Ivermectin 1.00
  Glycerol 4.0
  Acrylate C10-30 alkyl acrylate 0.2
  crosspolymer
  Methyl para-hydroxybenzoate 0.2
  Disodium EDTA 0.05
  Citric acid monohydrate 0.05
  Isopropyl palmitate 4.0
  Cetyl alcohol 3.5
  Stearyl monostearate 2.5
  Oleyl alcohol 2.0
  Ceteareth-20 3.0
  Sorbitan monostearate 2.0
  Dimethicone 200 20 cs 0.5
  Propyl para-hydroxybenzoate 0.1
  Propylene glycol 2.0
  Phenoxyethanol 1.0
  10% sodium hydroxide qs pH
  Water qs 100
   
as % by weight relative to the total weight of the emulsion.