| US 7,550,154 B2 | ||
| Methods of treatment with drug loaded polymeric materials | ||
| William Mark Saltzman, New Haven, Conn. (US); Tarek Fahmy, New Haven, Conn. (US); and Peter Fong, New Haven, Conn. (US) | ||
| Assigned to Yale University, New Haven, Conn. (US) | ||
| Filed on Jul. 30, 2007, as Appl. No. 11/830,212. | ||
| Application 11/830212 is a division of application No. 11/170803, filed on Jun. 30, 2005. | ||
| Claims priority of provisional application 60/677991, filed on May 05, 2005. | ||
| Claims priority of provisional application 60/628778, filed on Nov. 17, 2004. | ||
| Claims priority of provisional application 60/616821, filed on Oct. 07, 2004. | ||
| Claims priority of provisional application 60/585047, filed on Jul. 01, 2004. | ||
| Prior Publication US 2008/0014144 A1, Jan. 17, 2008 | ||
| Int. Cl. A61F 13/00 (2006.01); C07K 14/00 (2006.01); C07H 21/00 (2006.01) | ||
| U.S. Cl. 424—484 [514/2; 530/350; 977/773] | 19 Claims |
| 1. A tissue engineering matrix, wound dressing, or medical implant comprising polymeric microparticles or nanoparticles for
delivery of a therapeutic, nutritional, diagnostic or prophylactic agent incorporated on or within the microparticles or nanoparticles,
wherein the microparticles or nanoparticles are formed of a polymer having ligands present in a density of between about 1,000
and 10,000,000 ligands per square micron of microparticle or nanoparticle surface area,
wherein the ligands are inserted into or attached onto the surface of the polymeric microparticles or nanoparticles.
|