| US 7,548,782 B2 | ||
| Method for reversal of myocardial remodeling with electrical stimulation | ||
| Andrew P. Kramer, Stillwater, Minn. (US); Rodney W. Salo, Fridley, Minn. (US); Julio C. Spinelli, Shoreview, Minn. (US); and Bruce H. KenKnight, Maple Grove, Minn. (US) | ||
| Assigned to Cardiac Pacemakers, Inc., St. Paul, Minn. (US) | ||
| Filed on Sep. 01, 2006, as Appl. No. 11/469,620. | ||
| Application 11/469620 is a continuation of application No. 10/649468, filed on Aug. 27, 2003, granted, now 7,103,410. | ||
| Application 10/649468 is a continuation of application No. 09/844256, filed on Apr. 27, 2001, granted, now 6,628,988. | ||
| Prior Publication US 2006/0293716 A1, Dec. 28, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61N 1/362 (2006.01) | ||
| U.S. Cl. 607—9 [607/25] | 18 Claims |
| 1. A method, comprising:
identifying a stressed region of a patient's myocardium;
implanting a pacing device with one or more electrodes including a pacing electrode disposed at a first pacing site in proximity
to the stressed region;
programming the pacing device to deliver pacing therapy to the first pacing site in a manner such that the stressed region
of the myocardium is excited before other regions of the myocardium in order to subject the stressed region to less mechanical
stress when the myocardium contracts;
programming the pacing device to measure the patient's exertion level with an accelerometer or minute ventilation sensor;
and,
programming the pacing device to alternate between a pulse output sequence that pre-excites the stressed region and a pulse
output sequence that does not in accordance with the exertion level measurement such that pre-excitation of the stressed region
is discontinued during periods of increased exertion.
|