US 7,547,721 B1
Near infrared fluorescent contrast agent and fluorescence imaging
Naoto Miwa, Osaka (Japan); Michihito Inagaki, Osaka (Japan); Hiroaki Eguchi, Hyogo (Japan); Masafumi Okumura, Shiga (Japan); Yoshio Inagaki, Kanagawa (Japan); and Toru Harada, Kanagawa (Japan)
Assigned to Bayer Schering Pharma AG, Berlin (Germany); and Fuji Photo Film Co., Ltd., Kanagawa (Japan)
Appl. No. 10/149,917
PCT Filed Dec. 15, 1999, PCT No. PCT/EP99/09959
§ 371(c)(1), (2), (4) Date Oct. 17, 2002,
PCT Pub. No. WO01/43781, PCT Pub. Date Jun. 21, 2001.
Application 10/149917 is a continuation in part of application No. 09/787394, previously published as PCT/EP99/07088, filed on Sep. 16, 1999.
Claims priority of application No. 10-283301 (JP), filed on Sep. 18, 1998.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/404 (2006.01)
U.S. Cl. 514—414  [514/415] 4 Claims
 
1. A method of near infrared fluorescence imaging comprising introducing a pharmaceutical composition comprising a compound of the formula

OG Complex Work Unit Drawing
and a pharmaceutically acceptable carrier into a living body, exposing the body to excitation radiation, and detecting near infrared fluorescence from said compound.