R¹, R², R³, R⁴, R⁵ are independently selected from the group consisting of hydrogen, cyano, nitro, halo, hydroxy, C_1-4 alkyl optionally substituted by one or more hydroxy groups, or C_3-6 cycloalkyl which is further optionally substituted by one or more C_1-4 alkyl or halo groups, C_1-4 alkoxy, C_1-4 haloalkyl, C_1-4 haloalkoxy, phenyl, amino, NR^xR^y, or S(O)_nR¹⁰;

R⁶ is selected from the group consisting of hydrogen, —C_0-2alkyleneR⁷, —C_1-2alkyleneOR⁷, —C_0-2alkyleneC(O)R⁷, —C_1-2alkyleneOC(O)R⁷, —C_1-2alkyleneOC(O)OR⁷, —C_0-2alkyleneC(O)OR⁷, —C_1-2alkyleneN(H)C(O)R⁷, —C_1-2alkyleneN(R⁷)C(O)R⁷, —C_0-2alkyleneC(O)NHR⁷, —C_0-2alkyleneC(O)NR¹⁵R¹⁶, —C_1-2alkyleneNHC(O)NR¹⁵R¹⁶, —C_1-2alkyleneNR⁷C(O)NR¹⁵R¹⁶, —C_1-2alkyleneOC(O)NHR⁷, —C_1-2alkyleneOC(O)NR¹⁵R¹⁶, —C_0-2alkyleneCH═N(R⁷), —C_1-2alkyleneP(═O)(NR¹⁵R¹⁶)(NR¹⁵R¹⁶), —C_0-2alkyleneSi(R⁷)₃, and —C_0-2alkyleneS(O)R¹⁰;

where the C_0-2alkylene or C_1-2alkylene of R⁶ may, where chemically possible, optionally be substituted by one or more substituents selected from the group consisting of C_1-6 alkyl, C_3-6 cycloalkyl, C_1-4alkylene(C_3-6cycloalkyl), C_0-6alkylenephenyl, which C_{0- 2}alkylene or C_1-2alkylene substituent may in turn be optionally further substituted, where chemically possible, by one or more substituents selected from the group consisting of hydrogen, cyano, nitro, halo, formyl, oxo, hydroxy, C(O)OH, C_1-4alkyl, C_1-4alkyleneC_3-6cycloalkyl, C_1-4alkoxy, C_1-4alkyleneC_1-4alkyoxy, —C(O)OC_1-4alkyl, C_1-4haloalkyl, C_1-4haloalkoxy, amino, C_1-4alkylamino, C_1-4dialkylamino, and S(O)_nR¹⁰;

where each R⁷, R¹⁵ and R¹⁶, where chemically possible, is independently selected from the group consisting of hydrogen, C_1-8alkyl, C_2-6alkenyl, C_2-6alkynyl, C_3-8cycloalkyl, C_1-4alkylene(C_3-6cycloalkyl), C_1-4alkyleneC_1-4alkoxy, C_1-6haloalkyl, C_0-6alkylenephenyl, C_0-6alkylenenaphthyl, C_0-6alkylene(tetrahydronaphthyl), and C_0-2alkylene(Het), where Het is selected from oxetanyl, tetrahydropyranyl, piperidinyl, morpholinyl, furyl, pyridyl, benzofuranyl, benzothiazolyl, indolyl, 2,3-benzodioxolyl, 2,3-dihydro-1,4-benzodioxinyl, indolyl and 1,5-naphthyridinyl;

or R¹⁵ and R¹⁶ together with the nitrogen to which they are attached may form a three to seven-membered saturated or unsaturated heterocyclic ring optionally containing one or more further N, O or S atoms or SO₂ groups;

where each of the above R⁷, R¹⁵ or R¹⁶ groups may independently include one or more optional substituents where chemically possible selected from hydrogen, cyano, nitro, halo, formyl, oxo, hydroxy, C(O)OH, C_1-4alkyl, C_2-4alkenyl, C_2-4alkynyl, C_3-6cycloalkyl, C_1-4alkyleneC_3-6cycloalkyl, C_1-4alkoxy, C_1-4alkyleneC_1-4alkyoxy, C_1-4alkoxyC_1-4 alkoxy, C_1-4alkanoyl, —C(O)OC_1-4alkyl, C_1-4haloalkyl, C_3-6halocycloalkyl, C_1-4haloalkoxy, C_1-4haloalkanoyl, —C(O)OC_1-4haloalkyl, phenyl, 4-halophenyl, 4-alkoxyphenyl, 2-cyanophenyl, phenoxy, 4-halophenoxy, benzyloxy, 4-halobenzyloxy, benzoyl, pyrazolyl, triazolyl, 2-halo-4-pyrimidinyl, 2-phenylethyl, amino, C_1-4alkylamino, C_1-4 dialkylamino, C(O)N(C_1-4alkyl)₂, N(C_1-4alkylene)C(O)(C_1-4alkyl) and S(O)_nR¹⁰;

R⁸ and R⁹ are independently selected from the group consisting of hydrogen, C_1-4 alkyl, C_1-4 alkoxy, C_1-4 haloalkyl, C_1-4 haloalkoxy and C_0-4 alkylenephenyl but with the proviso that R⁸ and R⁹ are not both hydrogen;

where each of R⁸ and R⁹ may independently include one or more optional substituents where chemically possible selected from hydrogen, cyano, halo, hydroxy, C_1-4 alkyl, C_3-6 cycloalkyl, C_1-4 alkoxy, —C(O)OC_1-4 alkyl, C_1-4 haloalkyl, C_1-4haloalkoxy, and S(O)_nR¹⁰;

or R⁸ and R⁹ together with the carbon to which they are attached may form a three to six membered carbocyclic, saturated ring, which ring is optionally substituted with one or more substituents selected from the group consisting of halo, C_1-2 alkyl, C_1-2 alkoxy, C_1-2 haloalkyl, C_1-2 haloalkoxy;

R¹¹ and R¹² are independently selected from the group consisting of hydrogen, halo, cyano, C_1-4 alkyl, C_1-4 alkoxy, C_1-4 haloalkyl, and C_1-4 haloalkoxy;

where R^x and R^y are independently selected from hydrogen, C_1-4 alkyl, C_1-4 haloalkyl, and S(O)_nR¹⁰;

each n is independently 0, 1 or 2;

and each R¹⁰ is independently hydrogen, hydroxy, C_1-4 alkyl, C_1-4 haloalkyl, 4-halophenyl, amino, C_1-6 alkyl amino and di C_1-6 alkyl amino; or a pharmaceutically acceptable salt thereof.