US 7,544,835 B2
Carboxylic acid derivative and salt thereof
Fumiyoshi Matsuura, Brookline, Mass. (US); Eita Emori, Ibaraki (Japan); Masanobu Shinoda, Ibaraki (Japan); Richard Clark, Ibaraki (Japan); Shunji Kasai, Ibaraki (Japan); Hideki Yoshitomi, Ibaraki (Japan); Kazuto Yamazaki, Ibaraki (Japan); Takashi Inoue, Ibaraki (Japan); Sadakazu Miyashita, Ibaraki (Japan); Taro Hihara, Ibaraki (Japan); Hitoshi Harada, Ibaraki (Japan); and Kaya Ohashi, Toyko (Japan)
Assigned to Eisai R&D Management Co., Ltd., Bunkyo-Ku (Japan)
Appl. No. 10/472,543
PCT Filed Apr. 18, 2002, PCT No. PCT/JP02/03866
§ 371(c)(1), (2), (4) Date Oct. 22, 2003,
PCT Pub. No. WO02/100812, PCT Pub. Date Dec. 19, 2002.
Claims priority of application No. 2001-123346 (JP), filed on Apr. 20, 2001; and application No. 2002-036274 (JP), filed on Feb. 14, 2002.
Prior Publication US 2004/0102634 A1, May 27, 2004
Int. Cl. C07C 55/28 (2006.01); C07C 63/00 (2006.01)
U.S. Cl. 562—489  [562/405; 562/488] 19 Claims
 
1. A carboxylic acid compound represented by the following formula (I), a salt thereof, or an ester thereof

OG Complex Work Unit Drawing
wherein
R1 represents a C1-6 alkoxy group;
L represents a single bond or a C1-6 alkylene group which may have one or more substituents selected from C1-6 alkyl groups;
M represents a C1-6 alkylene group:
T represents a single bond, a C1-3 alkylene group, or a C2-3 alkynylene group;
W represents a carboxyl group;

OG Complex Work Unit Drawing
represents a single bond or a double bond;
X is a group represented by the formula:

OG Complex Work Unit Drawing
wherein n represents 1 to 5; RX2 and RX3 are the same as or different from each other and each represents a hydrogen atom, a hydroxy group, a halogen atom, a C1-6 alkoxy group, or a C1-6 hydroxyalkyl group, provided that at least one of Rx2 and Rx3 in the compound is a group other than a hydrogen atom; and Q3 and Q4 are the same as or different from each other and each represents an oxygen atom or (O)S(O);
Y is a phenyl group or a C3-7 alicyclic hydrocarbon group, each of which may have one to 4 substituents selected from the group consisting of halogen atoms, cyano groups, C1-6 alkyl groups, C1-4 alkoxy groups, C1-6 haloalkyl groups, and C1-6 hydroxyalkyl groups; and
the ring Z is a phenyl group.