US 7,544,828 B2
Process for preparation of Bicalutamide
Anil Kumar Shukla, Sahibabad (India); Golak Chandra Maikap, Sahibabad (India); and Shiv Kumar Agarwal, Sahibabad (India)
Assigned to Dabur Pharma Limited, Kolkata (India)
Filed on Oct. 17, 2006, as Appl. No. 11/582,716.
Claims priority of application No. 1187/2005 (IN), filed on Dec. 27, 2005.
Prior Publication US 2007/0149800 A1, Jun. 28, 2007
Int. Cl. C07D 255/00 (2006.01)
U.S. Cl. 558—411  [558/303] 23 Claims
 
1. A process for preparation of Bicalutamide of formula (I),

OG Complex Work Unit Drawing
comprising:
oxidizing of compound of formula (II),

OG Complex Work Unit Drawing
with potassium permanganate in presence of water or with potassium permanganate in the presence of a mixture of water and water miscible solvent; and
isolating Bicalutamide of formula (I).