| US 7,544,816 B2 | ||
| (−)-Epigallocatechin gallate derivatives for inhibiting proteasome | ||
| Tak-Hang Chan, Hong Kong (China); Wai-Har Lam, Hong Kong (China); Larry Ming-Cheung Chow, Hong Kong (China); Qing Ping Dou, Detroit, Mich. (US); Deborah Joyce Kuhn, Detroit, Mich. (US); and Aslamuzzaman Kazi, Detroit, Mich. (US) | ||
| Assigned to The Hong Kong Polytechnic University, Hong Kong Sar (China); Wayne State University, Detroit, Mich. (US); University of South Florida, Tampa, Fla. (US); and McGill University, Montreal, Quebec (Canada) | ||
| Filed on Aug. 19, 2004, as Appl. No. 10/921,332. | ||
| Prior Publication US 2006/0041010 A1, Feb. 23, 2006 | ||
| Int. Cl. C07D 311/82 (2006.01); A61K 31/35 (2006.01) | ||
| U.S. Cl. 549—399 [514/456] | 34 Claims |
1. A compound for inhibiting proteasome having the formula:
 wherein
R1 is selected from the group consisting of —H and C1 to C6 acyl group;
R2 is selected from the group consisting of —OH and C1 to C6 acyloxyl group; and
R3 and R4 are —H.
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