| US 7,544,708 B2 | ||
| Azabicyclo derivatives as muscarinic receptor antagonists | ||
| Mohammad Salman, Haryana (India); Anita Mehta, Buffalo Grove, Ill. (US); Pakala Kumara Savithru Sarma, Haryana (India); Shankar Jayram Shetty, Haryana (India); Sankaranarayanan Dharmarajan, Haryana (India); Naresh Kumar, Haryana (India); Arundutt Vishwanatham Silamkoti, Secunderabad (India); and Anita Chugh, Delhi (India) | ||
| Assigned to Ranbaxy Laboratories Limited, Gugaon (India) | ||
| Appl. No. 10/520,572 PCT Filed Apr. 11, 2003, PCT No. PCT/IB03/01367 § 371(c)(1), (2), (4) Date Jan. 19, 2006, PCT Pub. No. WO2004/005252, PCT Pub. Date Jan. 15, 2004. |
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| Claims priority of application No. PCT/IB02/02663 (WO), filed on Jul. 08, 2002. | ||
| Prior Publication US 2006/0111425 A1, May 25, 2006 | ||
| Int. Cl. A61K 31/40 (2006.01); C07D 209/44 (2006.01) | ||
| U.S. Cl. 514—412 [548/515] | 7 Claims |
1. A compounds having the structure of Formula I:
 Ar represents an aryl ring which may be unsubstituted or substituted by one to three substituents independently selected from
lower alkyl (C1-C4), lower perhalo alkyl (C1-C4), cyano, hydroxy, nitro, lower alkoxy (C1-C4), lower perhalo alkoxy (C1-C4), unsubstituted amino, N-lower alkyl (C1-C4) or -aryl amino, amino carbonyl, or N-lower alkyl (C1-C4) or -aryl amino carbonyl;
R1 represents a hydrogen, hydroxy, hydroxy methyl, substituted or unsubstituted amino, alkoxy, carbamoyl or halogen;
R2 represents alkyl, C3-C7 cycloalkyl ring, a C3-C7 cyclo alkenyl ring, an aryl, heterocyclic or a heteroaryl ring having 1 to 2 hetero atoms; the aryl, heteroaryl, heterocyclic
or a cycloalkyl ring may be unsubstituted or substituted by one to three substituents independently selected from lower alkyl
(C1-C4), lower perhalo alkyl (C1-C4), cyano, hydroxy, nitro, lower alkoxycarbonyl, halogen, lower alkoxy (C1-C4), lower perhalo alkoxy (C1-C4), unsubstituted amino, N-lower alkyl (C1-C4) or -aryl amino, amino carbonyl, or N-lower alkyl (C1-C4) or -aryl amino carbonyl;
W represents (CH2)p, wherein p represents 0 to 1;
X represents no atom;
Y represents (CH2)q wherein q represents 0;
Z represents oxygen, sulphur, or NR10, wherein R10 represents hydrogen or C1-6 alkyl;
Q represents —(CH2)n—, wherein n represents 0 to 4, CHR8, wherein R8 represents H, OH, C1-6, alkyl, C1-6 alkenyl, or C1-6 alkoxy, or Q represents CH2CHR9, wherein R9 represents H, OH, lower alkyl (C1-C4) or lower alkoxy (C1-C4); and
R6 and R7 are independently selected from H, CH3, COOH, CONH2, NH2, and CH2NH2.
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