	US 7,544,685 B2
	2,3-dihydroindole compounds
Benny Bang-Andersen, Copenhagen S (Denmark); Krestian Larsen, Ringsted (Denmark); and Niels Mørk, Virum (Denmark)
Assigned to H. Lundbeck A/S, Valby-Copenhagen (Denmark)
Filed on Aug. 15, 2006, as Appl. No. 11/504,186.
Claims priority of provisional application 60/709174, filed on Aug. 17, 2005.
Prior Publication US 2007/0043058 A1, Feb. 22, 2007
Int. Cl. A61K 31/496 (2006.01); A61K 31/437 (2006.01); C07D 209/14 (2006.01); C07D 487/04 (2006.01); A61K 31/454 (2006.01); A61K 31/4439 (2006.01); C07D 401/0411 (2006.01)

U.S. Cl. 514—253.04 [514/254.09; 514/323; 514/339; 544/362; 544/373; 546/201; 546/278.1]

24 Claims

1. A compound of formula I

wherein X—Y is N—CH₂;

Z is CR¹⁰or N;

R¹is A, A′ or A″

wherein * indicates the atom attached to N via a bond;

R²and R³are independently selected from hydrogen and C_1-6-alkyl;

R⁴-R⁷are independently selected from hydrogen, C_1-6-alkyl, C_1-6-alkoxy and halogen;

R⁸and R⁹are independently selected from hydrogen and halogen;

R¹⁰is hydrogen or halogen;

R¹¹and R¹²are independently selected from hydrogen and C_1-6-alkyl;

or enantiomers or pharmaceutically acceptable salts thereof.