| US 7,544,475 B2 | ||
| Depression gene | ||
| Donna Shattuck, Salt Lake City, Utah (US); Deanna Russell, Salt Lake City, Utah (US); Victor Abkevich, Salt Lake City, Utah (US); Chris Neff, Salt Lake City, Utah (US); Lisa Cannon-Albright, Salt Lake City, Utah (US); and Nicola Camp, Salt Lake City, Utah (US) | ||
| Assigned to IHC Health Services, Inc., , Utah (US) | ||
| Filed on May 17, 2007, as Appl. No. 11/750,019. | ||
| Application 11/441887 is a division of application No. 10/646396, filed on Aug. 21, 2003, granted, now 7,052,853. | ||
| Application 11/750019 is a continuation of application No. 11/441887, filed on May 26, 2006, granted, now 7,410,944. | ||
| Claims priority of provisional application 60/405334, filed on Aug. 21, 2002. | ||
| Claims priority of provisional application 60/428513, filed on Nov. 21, 2002. | ||
| Claims priority of provisional application 60/442492, filed on Jan. 24, 2003. | ||
| Prior Publication US 2008/0160519 A1, Jul. 03, 2008 | ||
| Int. Cl. C12Q 1/68 (2006.01) | ||
| U.S. Cl. 435—6 [536/23.1] | 5 Claims |
| 1. A method for detecting susceptibility to depression in an individual comprising:
a) drawing a sample of DNA from any tissue in the individual; and
b) using a diagnostic technique to detect a genetic alteration in the wild-type APAF1 allele (SEQ ID NO: 1), said genetic
alteration comprising at least one nucleic acid alteration selected from the group consisting of C1350G, A1394G, G2329A, A2345C,
A2857G, insertion of a T after nucleotide position 1299, T1244C, C1070T, C1437G, and A1874C,
wherein detection of said genetic alteration indicates that said individual is susceptible to depression.
|