| US 7,544,365 B2 | ||
| TRPV1+ sensory neurons control of β-cells stress and islet inflammation in diabetes | ||
| Hans-Michael Dosch, Toronto (Canada); Lan Tang, Toronto (Canada); Yin Chan, Toronto (Canada); and Michael Salter, Etobicoke (Canada) | ||
| Assigned to The Hospital for Sick Children, Toronto (Canada) | ||
| Filed on Dec. 14, 2006, as Appl. No. 11/638,830. | ||
| Prior Publication US 2008/0145386 A1, Jun. 19, 2008 | ||
| Int. Cl. A61K 45/00 (2006.01); A61K 39/00 (2006.01); C07K 5/00 (2006.01); C07K 14/00 (2006.01) | ||
| U.S. Cl. 424—278.1 [424/198.1; 530/300; 530/350; 514/866] | 1 Claim |
| 1. A process for normalizing elevated insulin resistance and initiating resolution of islet inflammation and islet infiltration
by immune cells in a mammal comprising:
delivering Substance P for ligation of neurokinin 1 receptors(NK1R receptors) by intra-arterial injection into the pancreas
of said mammal wherein rapid reversal of islet inflammation, abnormal insulin resistance and diabetes occurs.
|