US 7,544,361 B2
	Hetero type pentamer recombinant vaccine
Takeshi Arakawa, Naha (Japan); Masanao Kikukawa, Urasoe (Japan); Isao Shimabukuro, Naha (Japan); Masayuki Tadano, Okinawa (Japan); Yasunobu Matsumoto, Tokyo (Japan); Naotoshi Tsuji, Tsukuba (Japan); and Yoshiya Sato, Okinawa (Japan)
Assigned to Advanced Medical Biological Science Institute Co. Ltd., Nanjo-shi (Japan); and University of the Ryukyus, Nakagami-gun (Japan)
Appl. No. 10/565,595 PCT Filed Jul. 23, 2004, PCT No. PCT/JP2004/010459 § 371(c)(1), (2), (4) Date Jun. 29, 2006, PCT Pub. No. WO2005/010050, PCT Pub. Date Feb. 03, 2005.
Claims priority of application No. 2003-279156 (JP), filed on Jul. 24, 2003; and application No. 2003-412053 (JP), filed on Dec. 10, 2003.
Prior Publication US 2006/0246087 A1, Nov. 02, 2006
Int. Cl. A61K 39/385 (2006.01); A61K 39/12 (2006.01); A61K 39/295 (2006.01); A61K 9/28 (2006.01); C07K 19/00 (2006.01); C07K 17/00 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01); C12N 1/21 (2006.01)

U.S. Cl. 424—197.11  [424/186.1; 424/192.1; 424/193.1; 424/196.11; 424/201.1; 530/350; 536/23.1; 435/320.1; 435/252.3; 435/69.3; 435/69.7]

14 Claims

1. A heteropentamer composed of a fusion monomer comprising a fusion protein of an antigenic amino acid sequence and the amino acid sequence of a monomer of a pentameric mucous membrane-binding protein and a nonfusion monomer of the amino acid sequence of a monomer of the mucous membrane-binding protein.