| US 7,544,348 B2 | ||
| Liquid formulations for the prevention and treatment of mucosal diseases and disorders | ||
| Jeremy E. Jacob, Lewisville, Tex. (US); David P. Nowotnik, Colleyville, Tex. (US); and Christiane M. Baud, Dallas, Tex. (US) | ||
| Assigned to Access Pharmaceuticals, Inc., Dallas, Tex. (US) | ||
| Filed on Aug. 15, 2002, as Appl. No. 10/219,634. | ||
| Application 10/219634 is a continuation in part of application No. 10/077459, filed on Feb. 15, 2002. | ||
| Claims priority of provisional application 60/269049, filed on Feb. 15, 2001. | ||
| Prior Publication US 2003/0060486 A1, Mar. 27, 2003 | ||
| Int. Cl. A61K 8/00 (2006.01); A61K 8/18 (2006.01); A61K 47/32 (2006.01); A61Q 11/00 (2006.01) | ||
| U.S. Cl. 424—49 [424/401; 424/78.18; 424/78.24; 424/78.29; 424/78.31; 424/78.35; 514/772.1; 514/772.5; 514/772.6; 514/772.7; 514/780; 514/781; 514/782; 514/901] | 16 Claims |
| 1. A pseudoplastic liquid composition for treating or inhibiting an oral mucocutaneous disorder, said pseudoplastic liquid
composition having a zero shear viscosity at 37±1 degrees Celsius of 100-20,000 centipoise, comprising 0.1 to 2.0 wt/wt% of
one or more mucoadhesives, wherein the mucoadhesive(s) is/are selected from the group consisting of polyvinylpyrrolidone,
carboxymethylcellulose, dextran sulfate, hydroxyalkylcellulose, dermatan sulfate, a water-soluble vinyl polymer, chitosan,
guar gum, xanthan gum, tragacanth gum, pectin and polyacrylic acid; wherein said pseudoplastic viscous liquid composition,
when administered to an oral mucosa:
1) remains liquid when shear is applied due to swishing the liquid in the mouth; and
2) attaches to and coats the oral mucosa upon discontinuance of said shear.
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