| US 7,542,800 B2 | ||
| Method and apparatus for synchronizing neural stimulation to cardiac cycles | ||
| Imad Libbus, St. Paul, Minn. (US); Paul A. Haefner, Circle Pines, Minn. (US); Aaron McCabe, Minneapolis, Minn. (US); and Yi Zhang, Blaine, Minn. (US) | ||
| Assigned to Cardiac Pacemakers, Inc., St. Paul, Minn. (US) | ||
| Filed on Apr. 05, 2005, as Appl. No. 11/99,141. | ||
| Prior Publication US 2006/0224188 A1, Oct. 05, 2006 | ||
| Int. Cl. A61N 1/36 (2006.01) | ||
| U.S. Cl. 607—9 [607/2] | 20 Claims |

| 1. A neural stimulation system coupled to a living subject having a circulatory system, the neural stimulation system comprising:
a stimulation output circuit to deliver neural stimulation pulses;
a plurality of electrodes configured to sense a plurality of subcutaneous electrocardiogram (ECG) vectors indicative of cardiac
cycles each including a predetermined type timing reference event, the plurality of electrodes configured for placement external
to the circulatory system;
a reference event detection circuit coupled to the plurality of electrodes, the reference event detection circuit adapted
to detect the predetermined type timing reference event using the plurality of subcutaneous ECG vectors;
a cardiac parameter measurement circuit coupled to the plurality of electrodes and adapted to measure an atrioventricular
interval;
a stimulation control circuit coupled to the stimulation output circuit and the reference event detection circuit and adapted
to adjust delivery of neural stimulation pulses using the measured atrioventricular interval, the stimulation control circuit
including:
an offset interval generator adapted to produce an offset interval starting with the predetermined type timing reference event;
and
a pulse delivery controller adapted to start a delivery of a burst of the neural stimulation pulses when the offset interval
expires; and
an implantable housing configured to contain at least the stimulation output circuit, the reference event detection circuit,
the cardiac parameter measurement circuit, and the stimulation control circuit, the implantable housing including a hermetically
sealed can being an electrode of the plurality of electrodes.
|