	US 7,541,468 B2
	Process of preparing N-ureidoalkyl-piperidines
Percy H. Carter, Princeton, N.J. (US)
Assigned to Bristol-Myers Squibb Company, Princeton, N.J. (US)
Filed on Jun. 09, 2005, as Appl. No. 11/149,410.
Claims priority of provisional application 60/578784, filed on Jun. 10, 2004.
Prior Publication US 2005/0277666 A1, Dec. 15, 2005
Int. Cl. C07D 211/26 (2006.01)

U.S. Cl. 546—231 [546/207; 548/452]

7 Claims

1. A process of preparing a compound of formula (IV),

or salt or stereoisomer thereof: wherein

Pg, at each occurrence, is independently selected from an amine protecting group;

comprising the steps of reacting a compound of Formula II,

with a reducing agent to give a compound of Formula III;

reacting the compound of formula (III) with an amine of formula (IIa) using reductive amination to give the compound of formula (IV)