US 7,541,453 B2
	siRNA targeting aquaporin 4
Anastasia Khvorova, Boulder, Colo. (US); Angela Reynolds, Conifer, Colo. (US); Devin Leake, Denver, Colo. (US); William Marshall, Boulder, Colo. (US); Steven Read, Denver, Colo. (US); and Stephen Scaringe, Lafayette, Colo. (US)
Assigned to Dharmacon, Inc., Lafayette, Colo. (US)
Filed on Nov. 09, 2006, as Appl. No. 11/598,179.
Application 11/598179 is a continuation in part of application No. 10/940892, filed on Sep. 14, 2004.
Application 10/940892 is a continuation in part of application No. PCT/US2004/014885, filed on May 12, 2004.
Application PCT/US2004/014885 is a continuation in part of application No. 10/714333, filed on Nov. 14, 2003.
Claims priority of provisional application 60/426137, filed on Nov. 14, 2002.
Claims priority of provisional application 60/502050, filed on Sep. 10, 2003.
Prior Publication US 2007/0141602 A1, Jun. 21, 2007
Int. Cl. C07H 21/04 (2006.01)

U.S. Cl. 536—24.5

20 Claims

1. An siRNA molecule, wherein said siRNA molecule consists of: (a) a duplex region; and (b) 0-4 overhang regions that contain six or fewer nucleotides, wherein the duplex region consists of a sense region and an antisense region, wherein said sense region and said antisense region together form said duplex region and said duplex region is 19-30 base pairs in length and said antisense region comprises a sequence that is the complement of SEQ. ID. NO. 440.