US 7,541,362 B2
Heterocyclic dihydropyrimidine compounds
Karnail S. Atwal, Newtown, Pa. (US); Wayne Vaccaro, Yardley, Pa. (US); John Lloyd, Yardley, Pa. (US); Heather Finlay, Lawrenceville, N.J. (US); Lin Yan, Princeton, N.J. (US); and Rao S. Bhandaru, Belle Mead, N.J. (US)
Assigned to Bristol-Myers Squibb Company, Princeton, N.J. (US)
Filed on Dec. 06, 2006, as Appl. No. 11/634,574.
Application 11/634574 is a division of application No. 10/660878, filed on Sep. 12, 2003, granted, now 7,157,451, filed on Jan. 02, 2007.
Application 10/660878 is a division of application No. 09/729731, filed on Dec. 05, 2000, granted, now 6,706,720, filed on Mar. 16, 2004.
Claims priority of provisional application 60/236037, filed on Sep. 28, 2000.
Claims priority of provisional application 60/169091, filed on Dec. 06, 1999.
Prior Publication US 2007/0099899 A1, May 03, 2007
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/06 (2006.01); A61K 31/4025 (2006.01)
U.S. Cl. 514—259.3  [544/281] 8 Claims
 
1. A compound of Formula I*

OG Complex Work Unit Drawing
and enantiomers, diasteriomers and pharmaceutically acceptable salts thereof, wherein
X1, X2 and X3, together with the atoms to which they are bonded, form a ring which is

OG Complex Work Unit Drawing
R1 is H;
R2 is a substituted phenyl;
R3* is a mono or bicyclic heterocyclo or substituted heterocyclo having 3 to 10 ring members of which 1-3 members are heteroatoms selected from nitrogen atoms, oxygen atoms and/or sulfur atoms;
R4 is methoxymethyl or C1-6 alkyl;
R5 is H; and
R7 is H, C1-6 alkyl, C1-6 alkoxy or CF3.