US 7,541,328 B2
	Coupling proteins to a modified polysaccharide
Jurgen Hemberger, Aschaffenburg (Germany); Michele Orlando, The Hague (Netherlands); Klaus Sommermeyer, Rosbach v.d.H (Germany); Wolfram Eichner, Butzbach (Germany); Sven Frie, Bramois (Switzerland); Katharina Lutterbeck, Friedberg (Germany); Cornelius Jungheinrich, Bad Homburg (Germany); and Roland Scharpf, Ranstadt (Germany)
Assigned to Fresenius Kabi Deutschland GmbH, Bad Homburg v.d.H (Germany)
Appl. No. 10/506,367 PCT Filed Feb. 28, 2003, PCT No. PCT/EP03/02083 § 371(c)(1), (2), (4) Date Apr. 05, 2005, PCT Pub. No. WO03/074087, PCT Pub. Date Sep. 12, 2003.
Claims priority of application No. 102 09 821 (DE), filed on Mar. 06, 2002.
Prior Publication US 2005/0181985 A1, Aug. 18, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); C07K 14/00 (2006.01); C08B 31/00 (2006.01)

U.S. Cl. 514—2  [530/300; 530/350; 536/47]

19 Claims

1. A hydroxyethylstarch-protein conjugate, characterized in that the binding interaction between the hydroxyethylstarch molecule and the protein is a single covalent bonding which is the result of a coupling reaction between (i) the terminal aldehyde group of the hydroxyethylstarch molecule and (ii) a primary amino group of the protein to form a Schiff's base.