US 7,541,177 B2
Methods for identifying pathological conditions in a female subject
Amnon Kritzman, Zichron Yaakov (Israel); Nitsa G. Nachshon, Kibbutz Geva (Israel); and Yael Behar, Moshav Ein Ayala (Israel)
Assigned to Common Sense, Ltd., Caesarea (Israel)
Filed on Dec. 03, 2007, as Appl. No. 11/949,541.
Application 11/949541 is a continuation of application No. 11/105438, filed on Apr. 14, 2005, granted, now 7,314,752.
Application 11/105438 is a continuation in part of application No. 10/285499, filed on Nov. 01, 2002, granted, now 6,921,647.
Application 10/285499 is a continuation in part of application No. PCT/IL02/00588, filed on Jul. 18, 2002.
Application PCT/IL02/00588 is a continuation in part of application No. 09/907926, filed on Jul. 19, 2001, granted, now 6,627,394.
Claims priority of provisional application 60/365684, filed on Mar. 18, 2002.
Prior Publication US 2008/0086060 A1, Apr. 10, 2008
Int. Cl. C12M 1/34 (2006.01)
U.S. Cl. 435—288.7  [422/56; 604/358] 19 Claims
 
1. A method of identifying a pathological condition in a subject which comprises:
positioning a secretion-monitoring article to receive a biological fluid secreted from the subject, the secretion-monitoring article comprising a body that includes an absorbent material for absorbing the biological fluid and an indicator system having a hydrophobic chemical composition comprising an indicator agent and an ion-balance reagent which is a quaternary amine, wherein the indicator system provides an indication of physiological conditions associated with a pH or buffer capacity of the biological fluid, which indication is stable and remains indicative for at least 48 hours; and
viewing the article within the at least 48 hour period to identify the pathological condition based on the indication determined by the indicator system.