US 7,541,026 B2
	Alpha-amylase variants with altered properties
Scott D. Power, San Bruno, Calif. (US); Sandra W. Ramer, Sunnyvale, Calif. (US); and Andrew Shaw, San Francisco, Calif. (US)
Assigned to Danisco US Inc., Genencor Division, Palo Alto, Calif. (US)
Filed on Nov. 03, 2008, as Appl. No. 12/263,631.
Claims priority of provisional application 60/985619, filed on Nov. 05, 2007.
Claims priority of provisional application 60/026579, filed on Feb. 06, 2008.
Claims priority of provisional application 61/041075, filed on Mar. 31, 2008.
Claims priority of provisional application 61/059411, filed on Jun. 06, 2008.
Prior Publication US 2009/0117642 A1, May 07, 2009
Int. Cl. A61K 38/46 (2006.01); C12N 9/28 (2006.01)

U.S. Cl. 424—94.6  [435/202]

11 Claims

1. A variant of a parent G. stearothermophilus alpha-amylase having the amino acid sequence of SEQ ID NO. 1, 2 or 15, consisting of an alteration corresponding to position 242 of SEQ ID NO: 1, wherein (a) the alteration is a substitution of the amino acid which occupies the position with a different amino acid selected from the group consisting of A, E and Q, and (b) the variant has alpha-amylase activity.