| US 7,538,228 B2 | ||
| Oxazoline ligands for asymmetric catalysis | ||
| Xumu Zhang, State College, Pa. (US); and Duan Liu, State College, Pa. (US) | ||
| Assigned to The Penn State Research Foundation, University Park, Pa. (US) | ||
| Filed on Dec. 17, 2004, as Appl. No. 11/16,302. | ||
| Claims priority of provisional application 60/530313, filed on Dec. 17, 2003. | ||
| Prior Publication US 2005/0137403 A1, Jun. 23, 2005 | ||
| Int. Cl. C07F 9/50 (2006.01); C07D 277/10 (2006.01); C07D 263/10 (2006.01); C07D 233/20 (2006.01); C07D 207/20 (2006.01) | ||
| U.S. Cl. 548—119 [548/413; 548/146; 548/237; 548/354.1; 548/577] | 12 Claims |
1. A chiral ligand selected from the group consisting of compounds represented by the following formulas and their enantiomers:
 where x is PR2;
wherein each R is independently selected from the group consisting of: linear, branched or cyclic alkyl, linear, branched
or cyclic substituted alkyl, aryl, and substituted aryl, and a hetereocyclic group;
wherein Y is selected from the group consisting of: linear, branched or cyclic alkyl, linear, branched or cyclic substituted
alkyl, aryl, and substituted aryl, ferrocene, substituted ferrocene, a hetereocyclic group, and a hetereoaromatic group;
A is a substituent on the aromatic ring selected from the group consisting of: hydrogen, halide, alkoxyl, carboxylates, linear,
branched or cyclic alkyl, aryl, and a substituted aryl group; and
Z is selected from the group consisting of: oxygen sulfur, NH, NR, and CH2.
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