| US 7,538,222 B2 | ||
| N-substituted piperidine derivatives as serotonin receptor agents | ||
| Carl-Magnus Andersson, Hjärup (Sweden); Nathalie Schlienger, Frederiksberg (Denmark); Alma Fejzic, Frederiksberg (Denmark); Eva Louise Hansen, Højby (Denmark); and Jan Pawlas, Frederiksberg (Denmark) | ||
| Assigned to ACADIA Pharmaceuticals, Inc., San Diego, Calif. (US) | ||
| Filed on Dec. 12, 2005, as Appl. No. 11/299,566. | ||
| Application 11/299566 is a continuation of application No. 10/601070, filed on Jun. 20, 2003, granted, now 7,253,186. | ||
| Claims priority of provisional application 60/391269, filed on Jun. 24, 2002. | ||
| Prior Publication US 2006/0094758 A1, May 04, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. C07D 401/06 (2006.01); C07D 413/06 (2006.01) | ||
| U.S. Cl. 546—190 [544/129; 544/283; 546/207; 546/208; 546/209; 546/210; 546/211] | 24 Claims |
1. A compound of Formula I
 R1 is an optionally substituted (heterocyclyl)C1-6-alkyl;
R2 and R3are independently selected from the group consisting of hydrogen, C1-6-alkyl and halogen or such that R2 together with R3forms a 3-, 4-, 5-, 6-, or 7-membered ring system with the atoms of the piperidine ring;
m is 1;
n is selected from the group consisting of 1, 2, and 3;
Ar1 aryl or heteroaryl, optionally substituted with a substituent selected from the group consisting of C1-6-alkyl, C1-6-alkoxy, oxo, carboxyl, amino, hydroxy, nitro, alkylsulfonyl, alkylsulfenyl, alkylsulfinyl, C1-6-alkoxycarbonyl, C1-6-alkylcarbonyl, formyl, amino, mono- and di(C1-6-alkyl)amino, carbamoyl, mono- and di(C1-6-alkyl)aminocarbonyl, amino-C1-6-alkyl-aminocarbonyl, mono- and di(C1-6-alkyl)amino-C1-6-alkyl-aminocarbonyl, C1-6-alkylcarbonylamino, C1-6-alkylhydroxyimino, cyano, guanidino, carbamido, C1-6-alkanoyloxy, C1-6-alkylsulphonyloxy, dihalogen-C1-6-alkyl, trihalogen-C1-6-alkyl, haloalkoxy, heterocyclyl, halo, alkylamido, C1-6 hydroxyalkyl, C1-6 aminoalkyl, and sulfamoyl;
W is selected from the group consisting of oxygen and sulfur;
X is selected from the group consisting of optionally substituted methylene, optionally substituted ethylene, optionally substituted
propylene, optionally substituted vinylene, and CH2N(RN), wherein RN is selected from hydrogen and C1-6-alkyl; and
Ar2 is an optionally substituted aryl or heteroaryl.
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