US 7,538,195 B2
	Anti-IGF-I receptor antibody
Rajeeva Singh, Cambridge, Mass. (US); Daniel J. Tavares, Natick, Mass. (US); and Nancy E. Dagdigian, Acton, Mass. (US)
Assigned to Immunogen Inc., Waltham, Mass. (US)
Filed on Jun. 14, 2002, as Appl. No. 10/170,390.
Prior Publication US 2003/0235582 A1, Dec. 25, 2003
Int. Cl. C12P 21/08 (2006.01); C07K 16/00 (2006.01); A61K 39/395 (2006.01); A61K 49/00 (2006.01); C07H 21/04 (2006.01); G01N 33/574 (2006.01)

U.S. Cl. 530—387.3  [424/9.1; 424/133.1; 424/141.1; 424/143.1; 424/155.1; 424/178.1; 424/181.1; 424/183.1; 435/69.6; 435/70.21; 530/388.1; 530/388.22; 530/388.8; 530/391.7]

29 Claims

1. An isolated antibody or fragment thereof that specifically binds to IGF-IR, comprising at least one heavy chain variable region and at least one light chain variable region, wherein said heavy chain variable region comprises three complementarity-determining regions comprising the amino acid sequences of SEQ ID NOS:1-3, and wherein said light chain variable region comprises three complementarity-determining regions comprising the amino acid sequences of SEQ ID NOS:4-6.