| US 7,538,138 B2 | ||
| Amines as histamine-3 receptor ligands and their therapeutic applications | ||
| Marlon D. Cowart, Round Lake Beach, Ill. (US); Youssef L. Bennani, Shaker Heights, Ohio (US); Ramin Faghih, Lake Forest, Ill. (US); Gregory A. Gfesser, Waukegan, Ill. (US); and Lawrence A. Black, Libertyville, Ill. (US) | ||
| Assigned to Abbott Laboratories, Abbott Park, Ill. (US) | ||
| Filed on Apr. 08, 2005, as Appl. No. 11/102,415. | ||
| Application 11/102415 is a continuation of application No. 10/081207, filed on Feb. 25, 2002, granted, now 6,969,730. | ||
| Claims priority of provisional application 60/276793, filed on Mar. 16, 2001. | ||
| Prior Publication US 2005/0192277 A1, Sep. 01, 2005 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. C07D 405/04 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); A61K 31/343 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61P 25/00 (2006.01) | ||
| U.S. Cl. 514—469 [514/470; 514/430; 514/212.01; 514/252.01; 514/252.1; 514/256; 514/317; 514/336; 514/364; 548/335.5; 548/517; 546/196; 546/268.1; 544/62; 544/111; 544/238; 544/242; 544/336] | 11 Claims |
1. A compound of formula (I)
 A is a covalent bond;
D is O;
L is selected from the group consisting of lower alkylene, fluoroalkylene, and hydroxyalkylene;
P and Q taken together form a covalent bond or are both hydrogen;
R1 and R2 taken together with the nitrogen atom to which they are attached, together form a heterocycle;
R3 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylsulfinyl,
alkylsulfonyl, alkylthio, aryl, carboxy, carboxyalkyl, cyano, cyanoalkyl, formyl, halogen, haloalkoxy, haloalkyl, heterocycle,
hydroxy, hydroxyalkyl, mercapto, nitro, —NRARB, (NRARB)alkyl, (NRARB)carbonyl, and (NRARB)sulfonyl;
R4, R5, R6 and R7 are each independently selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylcarbonyloxy,
alkylsulfinyl, alkylsulfonyl, alkylthio, aryl, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, formyl, halogen, haloalkoxy,
haloalkyl, heterocycle, hydroxy, hydroxyalkyl, mercapto, nitro, —NRARB, (NRARB)alkyl, (NRARB)carbonyl, (NRARB)sulfonyl, -L2R20, and —R20L3R22;
L2 is selected from the group consisting of S(O), S(O)2, and C═(NOR21);
L3 is selected from the group consisting of a covalent bond, alkylene, alkenylene, O, S, C(═O), N(═OR21), and N(RA);
R20 is selected from the group consisting of aryl, heterocycle, and cycloalkyl;
R21 is selected from the group consisting of hydrogen and alkyl;
R22 is selected from the group consisting of aryl, heterocycle, and cycloalkyl;
RA and RB are each independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl and formyl;
provided that at least one of R4, R5, R6, or R7 is heterocycle.
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