| US 7,538,111 B2 | ||
| Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain | ||
| Martine Barth, Asnieres-les-Dijon (France); Michel Bondoux, Fontaine-les-Dijon (France); Pierre Dodey, Fontaine-les-Dijon (France); Christine Massardier, Dijon (France); Didier Thomas, Saint-Apollinaire (France); and Jean-Michel Luccarini, Dijon (France) | ||
| Assigned to Laboratoires Fournier S.A., Dijon (France) | ||
| Appl. No. 10/549,546 PCT Filed Mar. 24, 2004, PCT No. PCT/FR2004/000723 § 371(c)(1), (2), (4) Date Sep. 14, 2005, PCT Pub. No. WO2004/087700, PCT Pub. Date Oct. 14, 2004. |
||
| Claims priority of application No. 03 03602 (FR), filed on Mar. 25, 2003; and application No. 03 04530 (FR), filed on Apr. 11, 2003. | ||
| Prior Publication US 2006/0178360 A1, Aug. 10, 2006 | ||
| Int. Cl. A01N 43/58 (2006.01); A01N 43/60 (2006.01); A61K 31/50 (2006.01); A61K 31/495 (2006.01) | ||
| U.S. Cl. 514—250 [544/392; 544/359] | 8 Claims |
| 1. A compound, selected from the group consisting of:
a) a compound of formula:
 R1 represent a hydrogen, a halogen, a C1-C3 alkyl group, or a C1-C3 alkoxy group,
R2 represents a hydrogen, a halogen, a C1-C3 alkyl group, a C1-C3 alkoxy group, or a CF3 groups,
R3 represents a hydrogen, a halogen, a C1-C3 alkyl group or a C1-C3 alkoxy group,
R4 represents a hydrogen or a C1-C3 alkyl group,
Ra represents a C1-C4 alkyl group,
Y represents a —CH2—CH2—O—CH2— group,
X represents CH or a nitrogen atom,
p represents 2 or 3,
A represents a single bond, a nitrogen atom optionally substituted with a methyl group, or a straight or branched C1-C5 alkylene group optionally hydroxylated or of which one of the carbon atoms is oxidized into a ketone function, provided that
A and X together do not represent a nitrogen atom,
B represents a nitrogen-containing heterocycle or an amine group optionally substituted with one or two C1-C4 alkyl groups, or
b) addition salts of the above formula I compound with an acid.
|