| US 7,538,088 B2 | ||
| Method for inhibiting angiogenesis by administration of the extracellular domain of D1-1 polypeptide | ||
| David J. Anderson, Altadena, Calif. (US); Hai U. Wang, Eldorado Hills, Calif. (US); and Donghun Shin, Pasadena, Calif. (US) | ||
| Assigned to California Institute of Technology, Pasadena, Calif. (US) | ||
| Filed on Apr. 28, 2003, as Appl. No. 10/424,986. | ||
| Claims priority of provisional application 60/375904, filed on Apr. 26, 2002. | ||
| Prior Publication US 2004/0120955 A1, Jun. 24, 2004 | ||
| Int. Cl. A61K 38/17 (2006.01); C07K 14/47 (2006.01); C07K 14/515 (2006.01) | ||
| U.S. Cl. 514—12 [530/300; 530/324] | 6 Claims |
| 1. A method for inhibiting angiogenesis in a mammal, comprising administering to the mammal in need thereof an angiogenesis
inhibiting amount of a polypeptide comprising an extracellular portion of a D1-1 polypeptide having:
a) an amino acid sequence that is at least 95% identical to SEQ ID NO: 11; or,
b) an amino acid sequence encoded by a nucleic acid sequence that is at least 99% identical to SEQ ID NO: 8
wherein the polypeptide has angiogenesis inhibitory activity.
|