	US 7,537,887 B2
	Net, a transcription factor of the TCF family, as regulator of angiogenic factor expression
Bohdan Wasylyk, Illkirch (France); Marie-Christine Multon, Versailles (France); Abdelkader Ayadi, Strasbourg (France); and Hong Zheng, Strasbourg (France)
Assigned to Aventis Pharma S.A., Paris (France); and Institut National de la Sante de la Recherche Medicale, Paris (France)
Appl. No. 10/415,181 PCT Filed Oct. 23, 2001, PCT No. PCT/EP01/12987 § 371(c)(1), (2), (4) Date Oct. 03, 2003, PCT Pub. No. WO02/35235, PCT Pub. Date May 02, 2002.
Claims priority of application No. 00402968 (EP), filed on Oct. 25, 2000.
Prior Publication US 2004/0053833 A1, Mar. 18, 2004
Int. Cl. C12Q 1/00 (2006.01); C12Q 1/68 (2006.01); C12Q 1/02 (2006.01); C12Q 1/48 (2006.01); G01N 33/53 (2006.01)

U.S. Cl. 435—6 [435/4; 435/29; 435/7.1; 435/15]

17 Claims

1. A method for identifying a compound that modulates angiogenesis, said method comprising:

i) providing a composition comprising a mammalian NET transcription factor;

ii) contacting the composition with a compound; and

iii) assessing the ability of said compound to modulate function of said mammalian NET transcription factor;

wherein the ability of said compound to modulate said mammalian NET transcription factor function identifies said compound as a modulator of angiogenesis.