| US 7,537,787 B2 | ||
| Method for modulating glutamate and/or aspartate release in a central nervous system locus | ||
| Michael J. Kubek, Indianapolis, Ind. (US) | ||
| Assigned to Indiana University Research and Technology Corporation, Indianapolis, Ind. (US) | ||
| Filed on Jan. 07, 2004, as Appl. No. 10/753,116. | ||
| Application 10/753116 is a division of application No. 10/256691, filed on Sep. 27, 2002, granted, now 6,699,491. | ||
| Application 10/256691 is a division of application No. 09/897179, filed on Jul. 02, 2001, granted, now 6,491,939. | ||
| Application 09/897179 is a division of application No. 09/242776, granted, now 6,303,134, previously published as PCT/US97/15184, filed on Aug. 28, 1997. | ||
| Claims priority of provisional application 60/025171, filed on Aug. 29, 1996. | ||
| Prior Publication US 2004/0142042 A1, Jul. 22, 2004 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 9/14 (2006.01); A61K 9/50 (2006.01) | ||
| U.S. Cl. 424—502 [424/489] | 6 Claims |
| 1. A method for selectively increasing glutamate and/or aspartate release in a central nervous system locus in a site-specific
manner comprising the steps of:
selecting a central nervous system locus; and
providing prolonged release of thyrotropin-releasing hormone in situ at the central nervous system locus over a period of
time by placing at least one biodegradable, non-bursting, non-spherical microstructure into the central nervous system locus,
wherein the microstructure comprises 1-90% thyrotropin-releasing hormone and the remainder a biodegradable matrix.
|