| US 7,537,779 B2 | ||
| Antimicrobial medical devices | ||
| Shanta M. Modak, River Edge, N.J. (US); and Lester A. Sampath, Nyack, N.Y. (US) | ||
| Assigned to The Trustees of Columbia University in the City of New York, New York, N.Y. (US) | ||
| Filed on Jun. 20, 2003, as Appl. No. 10/600,257. | ||
| Application 10/600257 is a continuation of application No. PCT/US01/49205, filed on Dec. 21, 2001. | ||
| Application PCT/US01/49205 is a continuation in part of application No. 09/746670, filed on Dec. 22, 2000, granted, now 7,329,412. | ||
| Prior Publication US 2004/0052831 A1, Mar. 18, 2004 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61F 2/02 (2006.01) | ||
| U.S. Cl. 424—423 | 64 Claims |
| 1. An antimicrobial medical article prepared by a method comprising treating a surface of a polymeric medical article, for an effective period of time, with a solution comprising one or more solvents and an antimicrobial mixture consisting essentially of chlorhexidine free base and a water-soluble chlorhexidine salt, wherein the weight/weight ratio of chlorhexidine free base and the water-soluble chlorhexidine salt in the solution is between 1:1 and 1:5, and wherein the combined concentration of chlorhexidine free base and a water-soluble salt of chlorhexidine is about 2.00 percent (w/v) or greater. |