US 7,537,762 B2
	Human monoclonal antibodies to activin receptor-like kinase-1
Michael Aidan North, Rancho Santa Fe, Calif. (US); Karin Kristina Amundson, San Diego, Calif. (US); Vahe Bedian, Framingham, Mass. (US); Shelley Sims Belouski, Camarillo, Calif. (US); Dana Dan Hu-Lowe, Encinitas, Calif. (US); Xin Jiang, San Diego, Calif. (US); Shannon Marie Karlicek, San Diego, Calif. (US); Sirid Aimee Kellerman, Menlo Park, Calif. (US); James Arthur Thomson, San Diego, Calif. (US); Jianying Wang, San Diego, Calif. (US); Grant Raymond Wickman, San Diego, Calif. (US); and Jingchuan Zhang, Boulder, Colo. (US)
Assigned to Amgen Fremont, Inc., Fremont, Calif. (US); and Pfizer Inc., New York, N.Y. (US)
Filed on Sep. 06, 2006, as Appl. No. 11/517,530.
Claims priority of provisional application 60/715292, filed on Sep. 07, 2005.
Prior Publication US 2007/0065444 A1, Mar. 22, 2007
Int. Cl. A61K 39/395 (2006.01); C07K 16/40 (2006.01)

U.S. Cl. 424—146.1  [530/388.26]

15 Claims

1. A monoclonal antibody, or an antigen-binding portion thereof, that binds activin receptor-like kinase-1 (ALK-1), comprising a first variable domain comprising SEQ ID NO: 6 and a second variable domain comprising SEQ ID NO: 8.