| US 7,537,759 B2 | ||
| Modulating angiogenesis | ||
| Duojia Pan, Dallas, Tex. (US); Gerald M. Rubin, Berkeley, Calif. (US); and Hongbing Zhang, El Cerrito, Calif. (US) | ||
| Assigned to The Regents of the University of California, Oakland, Calif. (US) | ||
| Filed on Mar. 21, 2005, as Appl. No. 11/85,949. | ||
| Application 11/085949 is a division of application No. 10/068591, filed on Feb. 06, 2002, granted, now 6,872,750. | ||
| Application 10/068591 is a continuation of application No. 09/697854, filed on Oct. 27, 2000, granted, now 6,436,629. | ||
| Prior Publication US 2005/0171024 A1, Aug. 04, 2005 | ||
| Int. Cl. A01N 37/18 (2006.01); A61K 38/00 (2006.01) | ||
| U.S. Cl. 424—133.1 [514/2; 514/507; 514/513; 514/706; 514/75] | 17 Claims |
| 1. A method for inhibiting angiogenesis comprising the steps of:
specifically detecting activity of Kuz (also called ADAM 10) in a vertebrate animal predetermined to have a pathogenic angiogenesis;
contacting the animal with a metalloprotease inhibitor tospecifically inhibit the activity of the Kuz in the animal; and
detecting a resultant inhibition of angiogenesis in the animal using a measure selected from the group consisting of blood
flow paramenters, microvessel density, and vascular endothelial growth factor levels.
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