US 7,534,603 B2
	Fusion protein delivery system and uses thereof
John C. Kappes, Birmingham, Ala. (US); and Xiaoyun Wu, Birmingham, Ala. (US)
Assigned to The UAB Research Foundation, Birmingham, Ala. (US)
Filed on Oct. 15, 2002, as Appl. No. 10/272,147.
Application 10/272147 is a division of application No. 10/092929, filed on Mar. 07, 2002, abandoned.
Application 09/434641 is a division of application No. 08/947516, filed on Sep. 29, 1997, granted, now 6,001,985.
Application 10/092929 is a continuation of application No. 09/434641, filed on Nov. 05, 1999, abandoned.
Application 08/947516 is a continuation of application No. 08/421982, filed on Apr. 14, 1995, abandoned.
Prior Publication US 2004/0010135 A1, Jan. 15, 2004
Int. Cl. C12N 5/00 (2006.01); C07H 21/04 (2006.01)

U.S. Cl. 435—325  [435/252.33; 435/348; 435/320.1; 435/235.1; 536/23.4]

11 Claims

1. A nucleic acid molecule comprising a first nucleotide sequence expressing a Vpr polypeptide fused in frame to a second nucleotide sequence expressing a full length Integrase polypeptide, wherein said first nucleotide sequence expresses a full length Vpr polypeptide capable of association with an HIV viron, an SIV viron, or a virus like particle.