| US 7,534,448 B2 | ||
| Methods of treatment with drug loaded polymeric materials | ||
| William Mark Saltzman, New Haven, Conn. (US); Tarek Fahmy, New Haven, Conn. (US); Peter Fong, New Haven, Conn. (US); and Chris Breuer, Bethany, Conn. (US) | ||
| Assigned to Yale University, New Haven, Conn. (US) | ||
| Filed on Jun. 30, 2005, as Appl. No. 11/170,803. | ||
| Claims priority of provisional application 60/677991, filed on May 05, 2005. | ||
| Claims priority of provisional application 60/628778, filed on Nov. 17, 2004. | ||
| Claims priority of provisional application 60/616821, filed on Oct. 07, 2004. | ||
| Claims priority of provisional application 60/585047, filed on Jul. 01, 2004. | ||
| Prior Publication US 2006/0002971 A1, Jan. 05, 2006 | ||
| Int. Cl. A61K 9/14 (2006.01); C07K 14/00 (2006.01); C07H 21/00 (2006.01) | ||
| U.S. Cl. 424—417 [424/486; 424/502; 514/2; 530/350; 536/23.1; 977/773] | 17 Claims |
| 1. A method of treatment or inhibition of undesirable proliferation of cells comprising administering polymeric microparticles
or nanoparticles at a site of or adjacent to a region of undesired proliferation, wherein the microparticles or nanoparticles
have a diameter of between 50 nm and 1000 microns,
wherein the polymer is a hydrophobic polymer and the microparticles or nanoparticles comprise ligands with a hydrophile-lipophile
balance of less than 10,
wherein the ligands have a first end inserted into the surface of the microparticles or nanoparticles, and a second end facing
outwardly from the surface of the microparticles or nanoparticles,
wherein the microparticles or nanoparticles comprise an anti-proliferative factor, wherein the anti-proliferative factor is
selected from the group consisting of cytotoxic, cytostatic, and anti-angiogenic agents, and
wherein the microparticles or nanoparticles are administered in an amount effective to inhibit or decrease cellular proliferation
in the region of undesired proliferation.
|